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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $45 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Folic acid (Vitamin B9)(Vitamin M; Vitamin B9) is indispensable for the production and maintenance of new cells, for DNA/RNA synthesis. |
In vitro | Folic acid treatment induces dose-related increases in BRCA1 mRNA expression in HepG2, Huh-7D12, Hs578T, and JURKAT and in BRCA2 in HepG2, Hs578T, MCF7, and MDA-MB-157 cells. FA does not affect the corresponding normal cells or on any of the ovarian cell lines. Folic acid induces increased BRCA1 protein expression in Hs578T, but not HepG2 cells, whereas BRCA2 protein levels are undetectable. FA treatment does not alter DNA repair in liver-derived cells, whereas there are transient effects on breast-derived cells. There is no effect of FA treatment on BRCA1 or BRCA2 DNA methylation, although there is some variation in the methylation of specific CpG loci between some cell lines[1]. |
Cell Research | To determine the effect of FA supplementation on BRCA1 and BRCA2 mRNA expression, all cell lines were treated with 0, 25, 50, 75, or 100 nmol/L FA for 72 hours before harvesting in TRI Reagent according to the manufacturer’s instructions. (Only for Reference) |
Alias | Folate, Vitamin B9, Pteroylglutamic acid, Vitamin M, Folacin |
Molecular Weight | 441.4 |
Formula | C19H19N7O6 |
Cas No. | 59-30-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (113.28 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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