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Fraxinellone

Catalog No. T6S0071 CAS 28808-62-0

Synonyms: HIFs, Hypoxia-inducible factors, Fraxinellone, HIF-PH, STAT, Inhibitor, inhibit, HIF/HIF Prolyl-Hydroxylase

1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding-deterrent activity, inhibition of growth, and larvicidal activity. 3. Fraxinellone has effect in the midgut metabolism of Mythimna separata (M. separata), via protease (especially the weak alkaline trypsin-like enzyme), carboxylesterase and glutathione S-transferase.

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Fraxinellone, CAS 28808-62-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	HIFs, Hypoxia-inducible factors, Fraxinellone, HIF-PH, STAT, Inhibitor, inhibit, HIF/HIF Prolyl-Hydroxylase
Molecular Weight	232.279
Formula	C14H16O3
CAS No.	28808-62-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 42 mg/mL(180.8 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Sun Y , Qin Y , Gong F Y , et al. Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice[J]. Biochemical Pharmacology, 2009, 77(11):1717-1724.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Terpene Natural Product Library Anti-Cancer Metabolism Compound Library Traditional Chinese Medicine Monomer Library Glutamine Metabolism Compound Library Anti-Gastroenteritis Natural Product Library Natural Product Library for HTS Anti-Tumor Natural Product Library Immunology/Inflammation Compound Library Stem Cell Differentiation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.