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Divarasib

Catalog No. T9972 CAS 2417987-45-0

Synonyms: GDC-6036

Divarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 μM. Divarasib irreversibly locks KRAS G12C oncoprotein in an inactive state and inhibits tumor cell growth. It is being investigated for use in solid tumors, including non-small cell lung and colorectal cancers and other types of cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Divarasib, CAS 2417987-45-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 245.00
5 mg	In stock	$ 612.00
10 mg	In stock	$ 869.00
25 mg	In stock	$ 1,320.00
50 mg	In stock	$ 1,780.00
100 mg	In stock	$ 2,380.00

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Purity: 98.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Divarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 μM. Divarasib irreversibly locks KRAS G12C oncoprotein in an inactive state and inhibits tumor cell growth. It is being investigated for use in solid tumors, including non-small cell lung and colorectal cancers and other types of cancer.
Targets&IC50	KRas (G12C):<0.01 μM
In vitro	Divarasib exhibits a potency with an EC50 value of 2 nM in K-Ras G12C-alkylation HCC1171 cells.[2]
In vivo	Administration of Divarasib (10-100 mg/kg/day; PO for 7 days) results in a reduction in the ratio of free KRAS G12C.[1]

Synonyms	GDC-6036
Molecular Weight	622.06
Formula	C29H32ClF4N7O2
CAS No.	2417987-45-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (144.7 mM), Sonication is recommended.

References and Literature

1. Meng L, et al. Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach. Anal Chem. 2022;94(37):12927-12933. 2. Sushant Malhotra, et al. Fused ring compounds. WO2020097537A2. 3. Tran JC, et al. Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry. Anal Chem. 2023;95(11):4834-4839.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Inhibitor Library GPCR Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Bioactive Compound Library Clinical Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Compound 3344 KRAS inhibitor-6 Antineoplaston A10 TH-Z835 KRAS G12C inhibitor 19 SOS1/KRAS-IN-1 KRAS G12C inhibitor 14 PROTAC KRAS G12C degrader-3

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Divarasib 2417987-45-0 GPCR/G Protein MAPK Ras GDC 6036 GDC6036 GDC-6036 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.