Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSTO-IN-2 is a glutathione S-transferase inhibitor (IC50s: 1.4, 16.3, and 3.6 μM for GSTP1-1, GSTM1, and GSTA2).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | GSTO-IN-2 is a glutathione S-transferase inhibitor (IC50s: 1.4, 16.3, and 3.6 μM for GSTP1-1, GSTM1, and GSTA2). |
Targets&IC50 | GSTM1:16.3 μM , GSTP1-1:1.4 μM , GSTA2:3.6 μM |
In vitro | GSTO-IN-2 enhances the efficacy of chemotherapy drugs in two breast cancer cell lines (MCF-7 and MDA-MB-231) by inactivating GST isozymes. At a concentration of 50 μM, GSTO-IN-2 increases the effectiveness of cisplatin in reducing cell viability by up to 640% in MCF-7 and 270% in MDA-MB-231 cells. Similarly, when combined with thiotepa at concentrations of 25 and 50 μM, GSTO-IN-2 boosts the inhibition of cell viability by 170-320% in MCF-7 and 180-270% in MDA-MB-231 cells. |
Molecular Weight | 620.77 |
Formula | C33H52N2O9 |
CAS No. | 1202710-57-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GSTO-IN-2 1202710-57-3 Others GSTOIN2 GSTO IN 2 inhibitor inhibit