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GW604714X

Catalog No. T9235   CAS 853953-65-8
Synonyms: 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
GW604714X Chemical Structure
GW604714X, CAS 853953-65-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 116.00
5 mg In stock $ 289.00
10 mg In stock $ 478.00
25 mg In stock $ 789.00
50 mg In stock $ 1,080.00
100 mg In stock $ 1,480.00
500 mg In stock $ 2,970.00
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Purity: 99.03%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate
In vitro Direct measurement of pyruvate transport into rat liver and yeast mitochondria confirmed that these agents inhibited the mitochondrial pyruvate carrier (MPC) with K(i) values <0.1 μM. Inhibitor titrations of pyruvate-dependent respiration by heart mitochondria gave values for the concentration of inhibitor binding sites (pmol per mg protein) and their K(i) (nM) of 56.0 and 0.057 nM for the more hydrophobic GW604714X. GW604714X inhibited l-lactate transport by the plasma membrane monocarboxylate transporter MCT1, but at concentrations more than four orders of magnitude greater than the MPC.
Synonyms 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-
Molecular Weight 471.46
Formula C21H18FN5O5S
CAS No. 853953-65-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 5mg/ml(10.61mM), sonification is recommended.

DMSO: 4 mg/mL (8.48 mM)

TargetMolReferences and Literature

1. Hildyard J , Mml C , Dukes I D , et al. Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier[J]. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2005, 1707(2-3):221-230.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Cuproptosis Compound Library Mitochondria-Targeted Compound Library Bioactive Compounds Library Max Reprogramming Compound Library Metabolism Compound Library Inhibitor Library NO PAINS Compound Library Anti-Aging Compound Library

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Keywords

GW604714X 853953-65-8 Metabolism Mitochondrial Metabolism Inhibitor mitochondrial respiration Parkinson's Disease MCT1 pyruvate Alzheimer's Disease GW-604714X inhibit MPC 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- inhibitor

 

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