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Ginsenoside F4

Catalog No. TN1093 CAS 181225-33-2

Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the increase of Bax expression and decrease of Bcl-2 expression.

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Ginsenoside F4, CAS 181225-33-2

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10 mg	Inquiry	$ 550.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 570.00

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Description	Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the increase of Bax expression and decrease of Bcl-2 expression.
In vitro	In this study, the inhibitory and apoptosis-inducing effect of Ginsenoside F4 (GF4) from steamed notoginseng was investigated by using human lymphocytoma Jurkat (JK) cell. Cell Counting Kit-8 method was then used to assess the anti-proliferative effect of GF4, and Western blotting was run to detect the expression level of two apoptosis-related proteins including Bax and the Bcl-2. The results suggested that GF4 can effectively inhibit the proliferation of the cells, and Bax expression increased gradually, but Bcl-2 expression reduced with the increase of GF4 concentration[1]
Source	Natural Products > Araliaceae > Panax

Molecular Weight	767.01
Formula	C42H70O12
CAS No.	181225-33-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. The apoptosis-inducing effect of ginsenoside F4 from steamed notoginseng on human lymphocytoma JK cells.Nat Prod Res. 2013;27(24):2351-4.

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Keywords

Ginsenoside F4 181225-33-2 Apoptosis Immunology/Inflammation Proteases/Proteasome BCL MMP IL Receptor Ginsenoside F-4 inhibitor inhibit

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