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HBT1

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Catalog No. T8779Cas No. 489408-02-8

HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.

HBT1

HBT1

🥰Excellent
Purity: 99.52%
Catalog No. T8779Cas No. 489408-02-8
HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.
Pack SizePriceAvailabilityQuantity
10 mg$40In Stock
25 mg$79In Stock
50 mg$118In Stock
100 mg$198In Stock
200 mg$296In Stock
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Purity:99.52%
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Product Introduction

Bioactivity
Description
HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.
In vitro
HBT1 bound to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner.?The mode of HBT1 and LY451395 binding to a pocket in the LBD of AMPA-R differed: HBT1, formed hydrogen bonds with S518 in the LBD.?Lower agonistic profile of HBT1 may associate with its lower risks of bell-shaped responses in BDNF production in primary neurons.
Chemical Properties
Molecular Weight386.39
FormulaC16H17F3N4O2S
Cas No.489408-02-8
SmilesCc1cc(nn1CC(=O)Nc1sc2CCCCc2c1C(N)=O)C(F)(F)F
Relative Density.1.58 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 3.87 mg/mL (10 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5881 mL12.9403 mL25.8806 mL129.4029 mL
5 mM0.5176 mL2.5881 mL5.1761 mL25.8806 mL
10 mM0.2588 mL1.2940 mL2.5881 mL12.9403 mL

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