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IEM 1754 2HBr

IEM 1754 2HBr
IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
Catalog No. T6134Cas No. 162831-31-4
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Purity:99.72%
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IEM 1754 2HBr

Purity: 99.72%
Catalog No. T6134Alias IEM 1754 dihydrobromideCas No. 162831-31-4

IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
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Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$44In Stock
25 mg$97In Stock
50 mg$159In Stock
100 mg$237In Stock
1 mL x 10 mM (in DMSO)$55In Stock
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Product Introduction

Bioactivity
Description
IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
Targets&IC50
GluR1:6 μM
In vitro
IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits. [1] IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization. [2]
AliasIEM 1754 dihydrobromide
Chemical Properties
Molecular Weight412.25
FormulaC16H30N2·2HBr
Cas No.162831-31-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 75 mg/mL (181.9 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 50 mg/mL (121.29 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.4257 mL12.1286 mL24.2571 mL121.2856 mL
5 mM0.4851 mL2.4257 mL4.8514 mL24.2571 mL
10 mM0.2426 mL1.2129 mL2.4257 mL12.1286 mL
20 mM0.1213 mL0.6064 mL1.2129 mL6.0643 mL
50 mM0.0485 mL0.2426 mL0.4851 mL2.4257 mL
100 mM0.0243 mL0.1213 mL0.2426 mL1.2129 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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