Shopping Cart

Remove All

Your shopping cart is currently empty

IEM 1754 2HBr

Select Batch

Purity:99.72%

Resource Download

COA HPLC HNMR

IEM 1754 2HBr

Catalog No. T6134Cas No. 162831-31-4

IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$44	In Stock
25 mg	$97	In Stock
50 mg	$159	In Stock
100 mg	$237	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "IEM 1754 2HBr"

Product Introduction

Bioactivity

Description	IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
In vitro	IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits. [1] IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization. [2]
Alias	IEM 1754 dihydrobromide

Chemical Properties

Molecular Weight	412.25
Formula	C16H30N2·2HBr
Cas No.	162831-31-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 75 mg/mL (181.9 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (121.29 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4257 mL	12.1286 mL	24.2571 mL	121.2856 mL
5 mM	0.4851 mL	2.4257 mL	4.8514 mL	24.2571 mL
10 mM	0.2426 mL	1.2129 mL	2.4257 mL	12.1286 mL
20 mM	0.1213 mL	0.6064 mL	1.2129 mL	6.0643 mL
50 mM	0.0485 mL	0.2426 mL	0.4851 mL	2.4257 mL
100 mM	0.0243 mL	0.1213 mL	0.2426 mL	1.2129 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc