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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $33 | In Stock | |
5 mg | $51 | In Stock | |
10 mg | $81 | In Stock | |
25 mg | $137 | In Stock | |
50 mg | $196 | In Stock | |
100 mg | $296 | In Stock | |
1 mL x 10 mM (in DMSO) | $80 | In Stock |
Description | INCB 3284 is an orally available, selective and high affinity chemokine receptor 2 (CCR2) antagonist that inhibits monocyte chemotactic protein 1 from interacting with hCCR2.INCB 3284 is used in the study of hemorrhagic shock. |
Targets&IC50 | K+ channel (hERG):84 μM, MCP-1-hCCR2:3.7 nM |
In vitro | INCB3284 exhibited an IC50 of 3.7 nM for antagonizing the binding of monocyte chemoattractant protein-1 to hCCR2, an IC50 of 4.7 nM for antagonizing chemotactic activity, and an IC50 of 84 μM for inhibiting hERG potassium currents[1]. |
In vivo | INCB 3284 (1 mg/kg/day, intraperitoneal injection) or C021 significantly improved the neurological outcomes in AOM-treated mice, reduced microglial activation, decreased phosphorylation of ERK1/2, and attenuated the upregulation of cytokines induced by AOM[2]. |
Molecular Weight | 520.54 |
Formula | C26H31F3N4O4 |
Cas No. | 887401-92-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 0.1 mg/mL (insoluble) DMSO: 60 mg/mL (115.26 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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