Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 g | In stock | $ 50.00 | |
10 g | In stock | $ 59.00 | |
25 g | In stock | $ 68.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties. |
In vitro | Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2] |
In vivo | The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2] |
Source |
Synonyms | INO 495, NSC 20262 |
Molecular Weight | 268.23 |
Formula | C10H12N4O5 |
CAS No. | 58-63-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 49 mg/mL (182.7 mM)
H2O: 43 mg/mL (160.3 mM)
You can also refer to dose conversion for different animals. More
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Inosine 58-63-9 GPCR/G Protein Immunology/Inflammation Metabolism Neuroscience ROS Endogenous Metabolite Adenosine Receptor Inhibitor INO495 metabolism inhibit human INO 495 P1 receptor antinociceptive adenosine disease NSC 20262 INO-495 metabolite neuroprotective nucleoside antihyperalgesic NSC20262 NSC-20262 immunomodulatory antiallodynic Parkinson's inhibitor