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Inosine

Catalog No. T0437   CAS 58-63-9
Synonyms: INO 495, NSC 20262

Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.

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Inosine Chemical Structure
Inosine, CAS 58-63-9
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1 g In stock $ 50.00
10 g In stock $ 59.00
25 g In stock $ 68.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.78%
Purity: 99.51%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.
In vitro Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2]
In vivo The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2]
Source
Synonyms INO 495, NSC 20262
Molecular Weight 268.23
Formula C10H12N4O5
CAS No. 58-63-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 49 mg/mL (182.7 mM)

H2O: 43 mg/mL (160.3 mM)

TargetMolReferences and Literature

1. Krebs HA, et al. Biochim Biophys Acta, 1953, 12(1-2), 172-180. 2. Phillis JW, et al. J Cereb Blood Flow Metab, 1987, 7(6), 679-686. 3. Junqueira SC et al. Inosine, an Endogenous Purine Nucleoside, Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis: a Role for A2A Adenosine Receptor. Mol Neurobiol. 2016 Apr 30.

TargetMolCitations

1. Chen J, Li T, Huang D, et al.Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism.Journal of Pharmaceutical Analysis.2023

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Microbial Natural Product Library Human Endogenous Metabolite Library Anti-infective Natural Product Library FDA-Approved & Pharmacopeia Drug Library Pyroptosis Compound Library PBCRBS Traditional Chinese Medicine Compound Library

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A2B receptor antagonist 2 Xanthine amine congener A2B receptor antagonist 1 MRS 1754 APNEA VUF 5574 ZM241385 Nelonicline

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Keywords

Inosine 58-63-9 GPCR/G Protein Immunology/Inflammation Metabolism Neuroscience ROS Endogenous Metabolite Adenosine Receptor Inhibitor INO495 metabolism inhibit human INO 495 P1 receptor antinociceptive adenosine disease NSC 20262 INO-495 metabolite neuroprotective nucleoside antihyperalgesic NSC20262 NSC-20262 immunomodulatory antiallodynic Parkinson's inhibitor

 

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