JNJ-42253432

JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels.

Catalog No. T27683Cas No. 1428327-35-8

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Purity:99.08%

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COA LCMS HNMR HPLC

JNJ-42253432

Catalog No. T27683Cas No. 1428327-35-8

JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels.

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Pack Size	Price	Availability
1 mg	$118	In Stock
5 mg	$297	In Stock
10 mg	$448	In Stock
25 mg	$696	In Stock
50 mg	$936	In Stock
100 mg	$1,240	In Stock
500 mg	$2,530	In Stock
1 mL x 10 mM (in DMSO)	$339	In Stock

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Product Introduction

Bioactivity

Description	JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels.
Targets&IC50	P2X7:9.1(pKi, rat), P2X7:7.9(pKi, human)

Chemical Properties

Molecular Weight	446.63
Formula	C₂₈H₃₈N₄O
Cas No.	1428327-35-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90.0 mg/mL (201.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2390 mL	11.1949 mL	22.3899 mL	111.9495 mL
5 mM	0.4478 mL	2.2390 mL	4.4780 mL	22.3899 mL
10 mM	0.2239 mL	1.1195 mL	2.2390 mL	11.1949 mL
20 mM	0.1119 mL	0.5597 mL	1.1195 mL	5.5975 mL
50 mM	0.0448 mL	0.2239 mL	0.4478 mL	2.2390 mL
100 mM	0.0224 mL	0.1119 mL	0.2239 mL	1.1195 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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