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JNJ-55308942

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Purity:100%

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COA HNMR HPLC

JNJ-55308942

Catalog No. T37806Cas No. 2166558-11-6

JNJ-55308942 is a selective and brain-penetrant antagonist of P2X7 functional with IC50s of 10 and 15 nM and Kis of 7.1 and 2.9 nM for hP2X7 and rP2X7, respectively.

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Pack Size	Price	Availability
1 mg	$70	In Stock
5 mg	$172	In Stock
10 mg	$278	In Stock
25 mg	$537	In Stock
50 mg	$775	In Stock
100 mg	$1,080	In Stock
500 mg	$2,170	In Stock
1 mL x 10 mM (in DMSO)	$189	In Stock

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Product Introduction

Bioactivity

Description	JNJ-55308942 is a selective and brain-penetrant antagonist of P2X7 functional with IC50s of 10 and 15 nM and Kis of 7.1 and 2.9 nM for hP2X7 and rP2X7, respectively.
In vitro	JNJ-55308942 shows pKis of 8.1and 8.5 for recombinant hP2X7 and rP2X7. JNJ-55308942 attenuates IL-1β release in a concentration-dependent manner in human blood and in mouse blood and microglia[2].
In vivo	JNJ-55308942 (5 mg/kg; p.o.) shows the F of 81%, Vss of 1.7 L/kg, CL of 1.7 L/kg, Cmax of 3.7 mL min/kg, and AUC of 1747 ng/mL[1]. In male C57/BL6J mice, JNJ-55308942 (30 mg/kg; p.o.) significantly attenuates the effect of LPS on FSC, CD45 surface expression, and CD11b surface expression. In a model of Bacillus Calmette-Guerin-induced depression, JNJ-55308942 (30 mg/kg; orally) reverses the BCG-induced deficits of sucrose preference and social interaction (ED50 = 0.07 mg/kg). The P2X7 antagonist (3 mg/kg, orally) blocks Bz-ATP-induced brain IL-1β release in conscious rats[2].

Chemical Properties

Molecular Weight	425.32
Formula	C17H12F5N7O
Cas No.	2166558-11-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90 mg/mL (211.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3512 mL	11.7559 mL	23.5117 mL	117.5585 mL
5 mM	0.4702 mL	2.3512 mL	4.7023 mL	23.5117 mL
10 mM	0.2351 mL	1.1756 mL	2.3512 mL	11.7559 mL
20 mM	0.1176 mL	0.5878 mL	1.1756 mL	5.8779 mL
50 mM	0.0470 mL	0.2351 mL	0.4702 mL	2.3512 mL
100 mM	0.0235 mL	0.1176 mL	0.2351 mL	1.1756 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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