p2x7

P2X7 receptor antagonist-2 is a highly potent inhibitor of the P2X7 receptor, with a pIC50 value range of 6.5-7.5 and demonstrated efficacy in combating neuroinflammation [1].

P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor with an IC50 value of 0.01 nM for inhibiting IL-Iβ release, used in research on autoimmunity, inflammation, and cardiovascular disease [1].

P2X7-IN-2, a P2X7 receptor inhibitor, effectively suppresses IL-Iβ release, demonstrating an inhibitory concentration (IC50) value of 0.01 nM. This compound is utilized in the study of autoimmunity, inflammation, and cardiovascular disease.

2-Amino-p-cresol is an intermediate for the synthesis of a variety of compounds, including drugs, dyes, etc.; it is also used as a reagent for the synthesis of various polymers and an enzyme inhibitor.

p-(2-Methoxyethyl) phenol, an important kind of pharmaceutical intermediates, is primarily used in the synthesis of metoprolol which is effective drugs in the therapy of cardiovascular disease.

4-(2-Aminoethyl)amino-7-chloroquinoline (N1-(7-Chloroquinolin-4-yl)ethane-1,2-diamine) has potential anthelmintic and antitumor activity for the study of malaria.

Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagulation factor Xa, and it can be used in the study of thrombophlebitis, atherosclerosis, cerebral embolism, stroke and pulmonary embolism.

Substance P (1-7) 2TFA(68060-49-1(free base)) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

MitoBloCK-6 is an effective inhibitor of Erv1/ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cytochrome c.

[Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.

3-[7 ,7- dimethyl-5-oxo -6H-pyrrolo[3,4-b]pyridin-2-yI]-1H-indole-7 -carbonitrile is an androgen receptor modulator.

(2S)-1-O-p-coumaroyl-2-O-acetyl-3-O-β-D-glucopyranosylglycerol is a useful research compound for many research applications, including the fields of chemistry and life sciences, among others.

N,N-Bis(2-hydroxyethyl)-p-phenylenediamine is an intermediate compound.

Angiotensin 1/2 (5-7) acetate is a peptide with the sequence H2N-Ile-His-Pro-OH. Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It

Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM. Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is the R-isomer of Aleglitazar.

P-2'-deoxyribose (P-Nucleoside) is a deoxyribose that is widely found in organisms.

rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine has an EC50 value of ≤ 0.05 μM and an E.max value of > 250 μM for TREM2.

2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride is the impurity of Agomelatine, an antidepressant.

P2X7 receptor antagonist-3 is a potent inhibitor of the P2X7 receptor, with IC50 values of 4.2 nM in humans and 6.8 nM in rats, demonstrating its high efficacy across species.

P2X7 receptor antagonist-1 is a purinergic P2X7 receptor antagonist with anti-neuroinflammatory effects.

Compound 14a (P2X7 receptor antagonist-4) is a P2X7R antagonist with IC50 values of 64.7 nM in humans and 10.1 nM in mice. It inhibits the activation of the NLRP3 inflammasome, which subsequently reduces the expression of caspase-1, gasdermin D, IL-1β, and IL-18 in the kidneys of mice with sepsis-induced damage [1].

Vitexin 2''-O-p-coumarate (Vitexin2''-O-p-coumarate) is found in fenugreek seeds and promotes 2BS cell proliferation induced by H2O2.

7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor(with an IC50 of 183 μM) .

Substance P (7-11) (Substance P 7-11(TFA)) is a C-terminal fragment of Substance P .

Acetamide, N-(m-anisyl)-2-(p-butoxyphenoxy)-N-(2-morpholinoethyl)-, hydrochloride is a bioactive chemical.

2-(N,N-Dimethylaminomethylene ) amino-7-cyclopropylmethyl-7,9-dihydro-1H-purine-6,8-dione is a useful organic compound for research related to life sciences and the catalog number is TNU1330.

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65490 and the CAS number is 170791-09-0.

7-Amino-2H-chromen-2-one is a useful organic compound for research related to life sciences and the catalog number is T64948.

Acetamide, 2-chloro-N-(2-hydroxyethyl)-N-(p-(methylsulfonyl)benzyl)- is a bioactive chemical.

m-Dioxan-5-amine, 2-(p-chlorophenyl)-5-methyl- is a bioactive chemical.

2-Amino-4-chloro-5-iodo-N2-pivaloyl-7-[2-deoxy-3,5-di-O- (4-methylbenzoyl)-b-D-ribofuanosyl]-7H-pyrrolo[2,3-d]pyrimidine is a Nucleoside Derivative - 7-Deazapurine nucleoside; Halo-nucleoside.

2-Amino -7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-2,3,5-tri-O-actyl-xylofuranosyl)purine is a useful organic compound for research related to life sciences. The catalog number is TNU1331 and the CAS number is 2389988-52-5.

2-Amino-4-chloro-N2-pivaloyl-7-[2-deoxy-3,5-di-O-(4- methylbenzoyl)-b-D-ribofuanosyl]-7H-pyrrolo[2,3-d]pyrimidine is a Nucleoside Derivative - 7-Deazapurine nucleoside; Halo-nucleoside.

2-Furamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical.

2-Deacetyltaxuspine X is a natural product for research related to life sciences. The catalog number is TN2754 and the CAS number is 259678-73-4.

4-Chloro-7-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a Nucleoside - 7-deazapurine nucleoside, fluoronucleoside, halo nucleoside; Arabino-nucleoside.

Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, hydrochloride is a bioactive chemical.

Apigenin 7-[rhamnosyl-(1->2)-galacturonide] is a useful organic compound for research related to life sciences and the catalog number is T126160.

[(2R,3S,4R,5R)-3,4-diacetyloxy-5-[2-amino-7-(cyclopropylmethyl)-8-oxopurin-9-yl]oxolan-2-yl]methyl acetate is a useful organic compound for research related to life sciences and the catalog number is TNU1306.

Acetamide, N-(5-(p-aminophenoxy)pentyl)-2-phenyl- is a bioactive chemical.

2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol is a natural product for research related to life sciences. The catalog number is TN5697 and the CAS number is 2266586-31-4.

3-(7-Bromo-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a useful organic compound for research related to life sciences and the catalog number is T64758.

Apigenin 4'-O-(2'',6''-di-O-E-p-coumaroyl)glucoside is a natural product for research related to life sciences. The catalog number is TN6304 and the CAS number is 71781-79-8.

Acetamide, 2-(p-butoxyphenoxy)-N-(2-(dimethylamino)ethyl)-N-(m-ethoxyphenyl)-, hydrochloride is a bioactive chemical.

4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile is a useful organic compound for research related to life sciences and the catalog number is T66379.

2-Allyl-p-cresol is a biochemical.

(R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate is a useful organic compound for research related to life sciences and the catalog number is T65597.

2-Amino-3-(7-methyl-1H-indol-3-yl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T64952 and the CAS number is 17332-70-6.

Nucleoside Derivatives - 8-Aza-7-deaza-purine nucleoside

Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with broad-spectrum activity against both Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial properties, without the adverse hemolytic effects commonly associated with bee venom peptides [1].