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CE-224535
🥰Excellent
Catalog No. T14920Cas No. 724424-43-5
Alias PF-04905428
CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.
CE-224535
🥰Excellent
Purity: 98.68%
Catalog No. T14920Alias PF-04905428Cas No. 724424-43-5
CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 112 € | In Stock | |
| 5 mg | 282 € | In Stock | |
| 10 mg | 398 € | In Stock | |
| 25 mg | 645 € | In Stock | |
| 50 mg | 905 € | In Stock | |
| 100 mg | 1.216 € | In Stock | |
| 200 mg | 1.643 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 234 € | In Stock |
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Purity:98.68%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies. |
| In vitro | CE-224535 reduces leukocyte secretion of IL-1 and IL-18, thereby providing a novel therapeutic approach for the treatment of rheumatoid arthritis[1]. |
| In vivo | In rats, CE-224535 exhibits a low CLp (11 mL/min/kg) and a large Vdss (7.6 L/kg), resulting in a half-life of 2.4 hours. Oral administration of CE-224535 (5 mg/kg) produces Cmax levels approximately 90 times higher than its IC90 in human blood (0.21 μg/mL or 0.44 μM)[2]. |
| Alias | PF-04905428 |
| Molecular Weight | 480.94 |
| Formula | C22H29ClN4O6 |
| Cas No. | 724424-43-5 |
| Smiles | COC[C@H](O)Cn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O |
| Relative Density. | 1.47g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 95 mg/mL (197.53 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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