Shopping Cart
- Remove All
Your shopping cart is currently empty
A-804598
🥰Excellent
Catalog No. T3639Cas No. 1125758-85-1
Alias A 804598
A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
A-804598
🥰Excellent
Purity: 100%
Catalog No. T3639Alias A 804598Cas No. 1125758-85-1
A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $31 | In Stock | |
| 5 mg | $48 | In Stock | |
| 10 mg | $73 | In Stock | |
| 25 mg | $156 | In Stock | |
| 50 mg | $272 | In Stock | |
| 100 mg | $438 | In Stock | |
| 500 mg | $982 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $53 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "A-804598"
Gefapixant citrate
RO4926219 citrate, RO 4926219 citrate, MK-7264 citrate, MK7264 citrate, AF-219 citrate, AF219 citrate
T638462310299-91-1
Gefapixant citrate (AF-219 citrate) is an orally available, highly potent P2X3 receptor antagonist with antitussive properties that inhibits hP2X2/3. It can be used to study chronic cough.
- $58
Size
QTY
Ivermectin
MK-933
T113170288-86-7
Ivermectin (MK-933) is an activator of glutamate-gated chloride channels (GluCls) with antiparasitic activity.
- $32
Size
QTY
ATP disodium salt
Disodium adenosine triphosphate, ATP disodium, ATP, Adetide, Adenosine-Triphosphate, Adenosine 5'-triphosphate disodium salt
T1352987-65-5
ATP disodium salt (Adenosine-Triphosphate) is a P2 purinoceptor agonist.
- $50
Size
QTY
CTP disodium dihydrate
T788181012-87-5
CTP disodium dihydrate is an agonist of P2X4 purinergic receptor
- $50
Size
QTY
(E/Z)-Sivopixant
(E/Z)-S-600918
T96531640808-39-4In house
(E/Z)-Sivopixant ((E/Z)-S-600918) is a potent P2X3 receptor antagonist with an IC50 of 4 nM, suitable for respiratory diseases research.
- $88
Size
QTY
Brilliant blue G-250
Brilliant Blue G, BBG, Acid blue 90, Coomassie Brilliant Blue G
T207316104-58-1
Brilliant blue G-250 (Acid blue 90, Coomassie Brilliant Blue G) is an antagonist of the P2X7 purinergic receptor.
- $35
Size
QTY
Lappaconitine
(+)-Lappaconitine
T280632854-75-4
Lappaconitine ((+)-Lappaconitine), isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
- $40
Size
QTY
PSB-12062
N-(p-Methylphenylsulfonyl)phenoxazine
T1256855476-47-6
PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine) is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
- $30
Size
QTY
Aurintricarboxylic acid
NSC-4056, NSC4056, NSC 4056, ATA
T83334431-00-9
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.
- $30
Size
QTY
JNJ-42253432
T276831428327-35-8In house
JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels.
- $71
Size
QTY
Oxatomide
Oxatomida
T1983960607-34-3In house
Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be used to block ATP-induced currents in the human P2X7 receptor with an IC50 value of 0.95 μM.Oxatomide has an inhibitory effect on ATP-induced Ca2+ inward currents with an IC50 value of 0.43 μM.Oxatomide inhibits 5-hydroxytryptamine. Oxatomide inhibits 5-hydroxytryptamine with an IC50 of 0.43 μM.Oxatomide is used in the treatment of immune system diseases and in the study of hypersensitivity reactions.
- $32
Size
QTY
Opiranserin hydrochloride
T98331440796-75-7
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.
- $97
Size
QTY
Select Batch
Purity:100%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human). |
| Targets&IC50 | P2X7R (human):11 nM, P2X7R (rat):10 nM, P2X7R (rat):9 nM |
| In vitro | A-804598 effectively blocked IL-1β release in the THP-1 cells (IC50: 8.5 nM). It also blocked agonist-evoked pore formation in differentiated human THP-1 cells (IC50: 8.1 nM) with similar potency as in the calcium-influx assay. [1] |
| In vivo | According to the autoradiographic analysis of coronal rat brain sections, there was specific binding of [3H]-A-804598 throughout the rat brain. In the grey matter of the L4-L6 region of the rat spinal cord, it was also found that high levels of [3H]-A-804598 specific binding. [2] |
| Alias | A 804598 |
| Molecular Weight | 315.37 |
| Formula | C19H17N5 |
| Cas No. | 1125758-85-1 |
| Smiles | C[C@H](N(C(=N)NC#N)c1cccc2ncccc12)c1ccccc1 |
| Relative Density. | 1.17 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 31.5 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy A-804598 | purchase A-804598 | A-804598 cost | order A-804598 | A-804598 chemical structure | A-804598 in vivo | A-804598 in vitro | A-804598 formula | A-804598 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.