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A-804598

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Purity:100%

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COA HNMR LCMS

A-804598

Catalog No. T3639Cas No. 1125758-85-1

A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).

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Pack Size	Price	Availability
1 mg	$23	In Stock
2 mg	$31	In Stock
5 mg	$48	In Stock
10 mg	$73	In Stock
25 mg	$156	In Stock
50 mg	$272	In Stock
100 mg	$438	In Stock
500 mg	$982	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Product Introduction

Bioactivity

Description	A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
In vitro	A-804598 effectively blocked IL-1β release in the THP-1 cells (IC50: 8.5 nM). It also blocked agonist-evoked pore formation in differentiated human THP-1 cells (IC50: 8.1 nM) with similar potency as in the calcium-influx assay. [1]
In vivo	According to the autoradiographic analysis of coronal rat brain sections, there was specific binding of [3H]-A-804598 throughout the rat brain. In the grey matter of the L4-L6 region of the rat spinal cord, it was also found that high levels of [3H]-A-804598 specific binding. [2]
Alias	A 804598

Chemical Properties

Molecular Weight	315.37
Formula	C19H17N5
Cas No.	1125758-85-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31.5 mg/mL(100 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1709 mL	15.8544 mL	31.7088 mL	158.5439 mL
5 mM	0.6342 mL	3.1709 mL	6.3418 mL	31.7088 mL
10 mM	0.3171 mL	1.5854 mL	3.1709 mL	15.8544 mL
20 mM	0.1585 mL	0.7927 mL	1.5854 mL	7.9272 mL
50 mM	0.0634 mL	0.3171 mL	0.6342 mL	3.1709 mL
100 mM	0.0317 mL	0.1585 mL	0.3171 mL	1.5854 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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