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AZD9056 hydrochloride

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Purity:99.52%

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COA LCMS HPLC HNMR

AZD9056 hydrochloride

Catalog No. T14385Cas No. 345303-91-5

AZD9056 hydrochloride is a P2X7 inhibitor，Which plays a significant role in pain-causing diseases and inflammation.

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Pack Size	Price	Availability
1 mg	$39	In Stock
2 mg	$56	In Stock
5 mg	$93	In Stock
10 mg	$158	In Stock
25 mg	$352	In Stock
50 mg	$587	In Stock
100 mg	$839	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Product Introduction

Bioactivity

Description	AZD9056 hydrochloride is a P2X7 inhibitor，Which plays a significant role in pain-causing diseases and inflammation.
In vitro	The antagonist AZD9056 blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line, indicating a high selectivity of the antagonist for the P2X7 receptor.The P2X7-receptor antagonist AZD9056 has a clear inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells[1].
In vivo	Treatment with AZD9056 demonstrates analgesic and anti-inflammatory properties by reversing the MIA-induced upregulation of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP), and prostaglandin E2 (PGE2) in cartilage tissues.

Chemical Properties

Molecular Weight	455.46
Formula	C24H36Cl2N2O2
Cas No.	345303-91-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 48 mg/mL (105.39 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1956 mL	10.9779 mL	21.9558 mL	109.7791 mL
5 mM	0.4391 mL	2.1956 mL	4.3912 mL	21.9558 mL
10 mM	0.2196 mL	1.0978 mL	2.1956 mL	10.9779 mL
20 mM	0.1098 mL	0.5489 mL	1.0978 mL	5.4890 mL
50 mM	0.0439 mL	0.2196 mL	0.4391 mL	2.1956 mL
100 mM	0.0220 mL	0.1098 mL	0.2196 mL	1.0978 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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