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AZD9056 hydrochloride
Catalog No. T14385Cas No. 345303-91-5
AZD9056 hydrochloride is a P2X7 inhibitor，Which plays a significant role in pain-causing diseases and inflammation.
AZD9056 hydrochloride
Catalog No. T14385Cas No. 345303-91-5
AZD9056 hydrochloride is a P2X7 inhibitor，Which plays a significant role in pain-causing diseases and inflammation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $39 | In Stock | |
| 2 mg | $56 | In Stock | |
| 5 mg | $93 | In Stock | |
| 10 mg | $158 | In Stock | |
| 25 mg | $352 | In Stock | |
| 50 mg | $587 | In Stock | |
| 100 mg | $839 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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Purity:99.68%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AZD9056 hydrochloride is a P2X7 inhibitor，Which plays a significant role in pain-causing diseases and inflammation. |
| Targets&IC50 | P2X7:11.2 nM |
| In vitro | The antagonist AZD9056 blocks P2X7 receptors with an IC50 of 11.2 nM in the HEK-hP2X7 cell line, indicating high selectivity for the receptor. Additionally, AZD9056 exhibits a clear inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells[1]. |
| In vivo | Treatment with AZD9056 demonstrates analgesic and anti-inflammatory properties by reversing the MIA-induced upregulation of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP), and prostaglandin E2 (PGE2) in cartilage tissues. |
| Molecular Weight | 455.46 |
| Formula | C24H36Cl2N2O2 |
| Cas No. | 345303-91-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 48 mg/mL (105.39 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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