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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $293 | In Stock | |
5 mg | $722 | In Stock | |
10 mg | $987 | In Stock | |
25 mg | $1,520 | In Stock | |
50 mg | $1,980 | In Stock | |
100 mg | $2,760 | In Stock |
Description | JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression. |
Targets&IC50 | P2X7 receptor (human):8.46 (pIC50), P2X7 receptor (rat):8.81(pic50), P2X7 receptor (rat):8.81 (pIC50), P2X7 receptor (human):(pic50)8.46 |
In vitro | JNJ-54175446 is a selective purinergic P2X7 receptor (P2X7R) antagonist that attenuates the release of IL-1β/IL-18 from microglial cells[1]. |
In vivo | JNJ-54175446 (30 mg/kg, intraperitoneal) administered once daily significantly reduces spontaneous recurrent seizures in mice, persisting for several days after the end of treatment[1]. |
Alias | JNJ-5446 |
Molecular Weight | 440.78 |
Formula | C18H13ClF4N6O |
Cas No. | 1627902-21-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (113.44 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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