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JNJ-54175446

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Purity:99.83%

ee:100%

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COA CSFC FNMR HNMR HPLC LCMS ORP

JNJ-54175446

Catalog No. T15622Cas No. 1627902-21-9

JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression.

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Pack Size	Price	Availability
1 mg	$293	In Stock
5 mg	$722	In Stock
10 mg	$987	In Stock
25 mg	$1,520	In Stock
50 mg	$1,980	In Stock
100 mg	$2,760	In Stock

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Product Introduction

Bioactivity

Description	JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression.
Targets&IC50	P2X7 receptor (human):8.46 (pIC50), P2X7 receptor (rat):8.81(pic50), P2X7 receptor (rat):8.81 (pIC50), P2X7 receptor (human):(pic50)8.46
In vitro	JNJ-54175446 is a selective purinergic P2X7 receptor (P2X7R) antagonist that attenuates the release of IL-1β/IL-18 from microglial cells[1].
In vivo	JNJ-54175446 (30 mg/kg, intraperitoneal) administered once daily significantly reduces spontaneous recurrent seizures in mice, persisting for several days after the end of treatment[1].
Alias	JNJ-5446

Chemical Properties

Molecular Weight	440.78
Formula	C18H13ClF4N6O
Cas No.	1627902-21-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (113.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2687 mL	11.3435 mL	22.6871 mL	113.4353 mL
5 mM	0.4537 mL	2.2687 mL	4.5374 mL	22.6871 mL
10 mM	0.2269 mL	1.1344 mL	2.2687 mL	11.3435 mL
20 mM	0.1134 mL	0.5672 mL	1.1344 mL	5.6718 mL
50 mM	0.0454 mL	0.2269 mL	0.4537 mL	2.2687 mL
100 mM	0.0227 mL	0.1134 mL	0.2269 mL	1.1344 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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