Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 139.00 | |
25 mg | In stock | $ 287.00 | |
50 mg | In stock | $ 463.00 | |
100 mg | In stock | $ 682.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1. |
Targets&IC50 | Wnt:1.17μM |
In vitro | JW 67 inhibits the canonical?Wnt?signaling with an?IC50?of 1.17μM[1]. JW 67 (1 μM) increased concentration of AXIN2 and decreased the active form of β-catenin[1]. JW 67 (10 or 25μM) reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S[1]. |
Molecular Weight | 394.38 |
Formula | C21H18N2O6 |
CAS No. | 442644-28-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (152.14 mM)
You can also refer to dose conversion for different animals. More
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JW 67 442644-28-2 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin inhibit Wnt Inhibitor CK1 complex JW-67 β-catenin GSK-3b JW67 AXIN multiprotein APC inhibitor