Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 72.00 | |
25 mg | In stock | $ 129.00 | |
50 mg | In stock | $ 213.00 | |
100 mg | In stock | $ 322.00 | |
200 mg | In stock | $ 478.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV. |
Targets&IC50 | Influenza virus:2 μM , DNV:>5 μM |
In vitro | KIN101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5[1].KIN101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance[1]. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells[1]. KIN101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM[1]. |
Synonyms | 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene |
Molecular Weight | 395.22 |
Formula | C16H11BrO5S |
CAS No. | 610753-87-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32 mg/mL (80.97 mM)
You can also refer to dose conversion for different animals. More
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KIN101 610753-87-2 Microbiology/Virology Proteases/Proteasome Influenza Virus HCV Protease RSV Antifection virus Isoflavone 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene Hepatitis C virus Dengue hepatitis HCV Inhibitor DNV Viral RNA broad-spectrum IRF-3 KIN 101 KIN-101 inhibit inhibitor