Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively. Kuwanon E also inhibited the production of MUC5AC mucin induced by PMA from NCI-H292 cells,.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 5 days | $ 160.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 170.00 |
Description | Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively. Kuwanon E also inhibited the production of MUC5AC mucin induced by PMA from NCI-H292 cells,. |
In vitro | Nine flavonoids displaying cholinesterase inhibitory activity were isolated from the root bark oiMorus Ihou L., a cultivated edible plant. The isolated compounds were identified as a new flavone (1), 5'-geranyl-5,7,2',4'-tetrahydroxyflavone (2), kuwanon U (3), Kuwanon E (4), morusin (5), morusinol (6), cyclomorusin (7), neocyclomorusin (8), and kuwanon C (9). All compounds apart from compound 6 inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively. The new compound was char-actierized as S'-geranyl-4'-methoxv-5,7,2'-trihydroxyflavone (1). It showed the most potent inhibitory activity (K i = 3.1 μM for AChE, K i= 1.74 μM for BChE). Lineweaver-Burk and Dixon plots and their secondary replots indicated that flavones (5-9) with prenyl substitution on C-3 were noncompetitive inhibitors, whereas those unsubstituted (1 -4) at C-3 were mixed inhibitors of both AChE and BChE. |
Source |
Molecular Weight | 424.49 |
Formula | C25H28O6 |
CAS No. | 68401-05-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Kuwanon E 68401-05-8 Neuroscience AChR inhibitor inhibit