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LY 345899

Catalog No. T15827 CAS 10538-99-5

LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).

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LY 345899, CAS 10538-99-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 152.00
5 mg	In stock	$ 373.00
10 mg	In stock	$ 556.00
25 mg	In stock	$ 893.00
50 mg	In stock	$ 1,220.00
100 mg	In stock	$ 1,630.00
500 mg	In stock	$ 3,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 397.00

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Purity: 99.69%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).
Targets&IC50	MTHFD2:663 nM (Ki), MTHFD1:18 nM (Ki), MTHFD1:IC50 : 96 nM

Molecular Weight	471.42
Formula	C20H21N7O7
CAS No.	10538-99-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (265.16 mM), Sonication is recommended.

References and Literature

1. Schmidt A, et al. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry. 2000 May 30;39(21):6325-35. 2. Tedeschi PM, et al. Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development. Mol Cancer Res. 2015 Oct;13(10):1361-6. 3. Gustafsson R, et al. Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. Cancer Res. 2017 Feb 15;77(4):937-948.

Citations

1. Chen C, Lai X, Zhang Y, et al. NADPH Metabolism Determines the Leukemogenic Capacity and Drug Resistance of AML Cells. Cell reports. 2022 Apr 5;39(1):110607. 2. Wang J, Yu Z, Jiang Y, et al.Downregulation of MTHFD2 Inhibits Proliferation and Enhances Chemosensitivity in Hepatocellular Carcinoma via PI3K/AKT Pathway.Frontiers in Bioscience-Landmark.2024, 29(1): 35.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NO PAINS Compound Library Bioactive Compound Library Metabolism Compound Library Bioactive Compounds Library Max DNA Damage & Repair Compound Library Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LY 345899 10538-99-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism DHFR LY-345899 inhibit Inhibitor LY345899 Methylenetetrahydrofolate Dehydrogenase (MTHFD) inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.