Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).
Description | LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM). |
Targets&IC50 | RARγ:1.09 nM(ki) |
In vitro | The functional Ki for RARγ is 7.1±4.9 nM. The binding Kis of LY2955303 for RARα, RARβ, and RARγ are >1700, >2980, and 1.09 nM, respectively[1]. |
In vivo | A single dose of LY2955303(oral) showed a dose-response effect in rats with different weight-bearing reductions with an ED50 of 0.72 mg/kg[1]. |
Molecular Weight | 578.74 |
Formula | C36H42N4O3 |
CAS No. | 1433497-19-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (43.20 mM), Sonification and heating are recommended.
You can also refer to dose conversion for different animals. More
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LY2955303 1433497-19-8 Metabolism Others Retinoid Receptor inhibit Autophagy Retinoic acid receptors RAR/RXR Inhibitor LY 2955303 Retinoid X receptors LY-2955303 inhibitor