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LY450108

Catalog No. TQ0289 CAS 376594-67-1

LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.

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LY450108, CAS 376594-67-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 74.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 517.00
50 mg	In stock	$ 748.00
100 mg	In stock	$ 1,050.00
500 mg	In stock	$ 2,090.00
1 mL * 10 mM (in DMSO)	In stock	$ 197.00

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Purity: 100%

Biological Description

Chemical Properties

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Description

LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.

Molecular Weight	396.45
Formula	C19H22F2N2O3S
CAS No.	376594-67-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (113.51 mM)

H2O: 1 mg/mL (2.52 mM), Sonification and heating are recommended.

References and Literature

1. Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32. 2. O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. 3. Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142. 4. Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160(2):181-190.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Antidepressant Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library ReFRAME Related Library Neuronal Signaling Compound Library Bioactive Compound Library

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Related compounds with same targets

Decanoic Acid AMPA receptor antagonist-3 AMPA receptor modulator-5 SYM2206 Rislenemdaz Tat-NR2B9c CX546 SYM 2081

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LY450108 376594-67-1 Membrane transporter/Ion channel Neuroscience iGluR Inhibitor inhibit AMPA Parkinson's LY 450108 LY-450108 depression Ionotropic glutamate receptors inhibitor

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