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Leonurine hydrochloride

Catalog No. T4080 CAS 24735-18-0

Synonyms: SCM-198 hydrochloride, SCM-198 HCl

Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.

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Leonurine hydrochloride Chemical Structure

Leonurine hydrochloride, CAS 24735-18-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 52.00
10 mg	In stock	$ 79.00
25 mg	In stock	$ 129.00
50 mg	In stock	$ 192.00
100 mg	In stock	$ 283.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.47%

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Description	Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
In vitro	The treatment of Leonurine hydrochloride (10-50?μM) for 24?h increases apoptotic ratio from 4.9% to 11.5-61.3%, respectively. The inhibition effect of Leonurine hydrochloride on H292 cells is related to the generation of ROS and the loss of MMP. Leonurine hydrochloride can increase the phosphorylation level of p38 and reduce Akt phosphorylation. Furthermore, Leonurine hydrochloride treatment increases the expression levels of caspase-3, caspase-9 and Bax/Bcl-2[1]. In RAW 264.7 cells and mouse bone marrow monocytes (BMMs), Leonurine hydrochloride suppresses RANKL-induced osteoclastogenesis and actin ring formation in a dose-dependent manner [2].
In vivo	Leonurine hydrochloride can elevate the ET level and ET/NO ratio in rats with up-regulated ETA mRNA expression and induced abortions, but there is no change in ETB mRNA[3]. Compared with the model group, Leonurine hydrochloride treatment markedly reduces the volume of bleeding and intrauterine residual, and markedly shortens the duration of bleeding. Leonurine hydrochloride also obviously reinforces the tension and frequency of uterine contractions [4].
Source	Natural Products > Lamiaceae > Leonurus

Synonyms	SCM-198 hydrochloride, SCM-198 HCl
Molecular Weight	347.79
Formula	C14H22ClN3O5
CAS No.	24735-18-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Mao F, et al. Leonurine hydrochloride induces apoptosis of H292 lung cancer cell by a mitochondria-dependent pathway. Pharm Biol. 2015;53(11):1684-90. 2. Yuan, F., Xu, R., Jiang, D., He, X., Su, Q., Jin, C., & Li, X. (2015). Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways. Bone, 75, 128-137. doi: 10.1016/j.bone.2015.02.017 3. Li X, et al. Effect of leonurine hydrochloride on endothelin and the endothelin receptor-mediated signal pathway in medically-induced incomplete abortion in rats. Eur J Obstet Gynecol Reprod Biol. 2013 Jul;169(2):299-303. 4. Li X, et al. Effects of leonurine hydrochloride on medically induced incomplete abortion in early pregnancy rats. Eur J Obstet Gynecol Reprod Biol. 2011 Dec;159(2):375-80.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Anti-Cancer Active Compound Library Membrane Protein-targeted Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Target-Focused Phenotypic Screening Library Oxidation-Reduction Compound Library Natural Product Library for HTS Bioactive Compound Library Anti-Tumor Natural Product Library Anti-COVID-19 Compound Library

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Keywords

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