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MAK683 hydrochloride embryonic ectodermal development (EED) inhibitor, also a potent PRC2 inhibitor, blocked cancer cell proliferation (IC50=1.014nM), with IC50 values of 59, 26, and 89 nM measured in EED Alphascreen, ELISA, and LC-MS assays, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $437 | In Stock | |
10 mg | $655 | In Stock | |
25 mg | $996 | In Stock | |
50 mg | $1,430 | In Stock | |
100 mg | $1,930 | In Stock |
Description | MAK683 hydrochloride embryonic ectodermal development (EED) inhibitor, also a potent PRC2 inhibitor, blocked cancer cell proliferation (IC50=1.014nM), with IC50 values of 59, 26, and 89 nM measured in EED Alphascreen, ELISA, and LC-MS assays, respectively. |
In vitro | METHODS: Human cervical cancer HeLa cells were treated with MAK683 (1.5-370nM) for 72 hours, and H3K27me3 protein expression was observed by Western Blot experiment. RESULTS MAK683 dose-dependently inhibited H3K27me3 protein expression in HeLa, with an IC50 of approximately 1.014nM. [1] |
In vivo | METHODS: To detect anti-tumor activity in vivo, WT G401 or p16 knockout cells were washed and resuspended in cold PBS. The tumor cell mixture was then injected subcutaneously into female Balb/c nude mice. When the tumor volume reached about 60-350 mm, The mice were numbered and randomly assigned to the 100 mg/kg MAK683 treatment group, which was administered at 8 a.m. The mouse body weight and tumor volume were measured and recorded every 3 days. RESULTS MAK683 treatment significantly inhibited the proliferation of female mouse G401 WT or p16 KO cells. [1] |
Molecular Weight | 412.85 |
Formula | C20H18ClFN6O |
Cas No. | 2170606-94-5 |
Smiles | FC1=CC=C2C(CCO2)=C1CNC3=NC=C(C(C=CC=N4)=C4C)C5=NN=CN35.Cl |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 4.55 mg/mL (11.01 mM) 10% DMSO+90% Saline: 0.46 mg/mL (1.11 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
10% DMSO+90% Saline/DMSO
DMSO
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