Powder: -20°C for 3 years
In solvent: -80°C for 2 years
MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.
Description | MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor. |
In vitro | MAZ51 is able to block the proliferation of VEGFR-3-expressing human endothelial cells and is less potently able to induce their apoptosis.?MAZ51 also inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines[1]. |
In vivo | In vivo, MAZ51 significantly inhibits the growth of rat mammary carcinomas.?These data establish MAZ51 as a compound with antitumor properties that inhibits tumor growth directly and also indirectly by interfering with tumor-host interactions[1]. |
Molecular Weight | 314.38 |
Formula | C21H18N2O |
CAS No. | 163655-37-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 3.33 mg/ml(10.59 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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MAZ51 163655-37-6 Angiogenesis Apoptosis Tyrosine Kinase/Adaptors VEGFR EGFR growth phosphorylation Inhibitor inhibit PDGFRβ MAZ 51 tumor VEGF-D indolinone IGF-1R VEGF-C Vascular endothelial growth factor receptor ligand-induced MAZ-51 proliferation inhibitor