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ML 254

🥰Excellent
Catalog No. T8862Cas No. 1428630-86-7

ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents.

ML 254

ML 254

🥰Excellent
Purity: 99.94%
Catalog No. T8862Cas No. 1428630-86-7
ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents.
Pack SizePriceAvailabilityQuantity
1 mg$51In Stock
5 mg$122In Stock
10 mg$197In Stock
25 mg$455In Stock
50 mg$672In Stock
100 mg$956In Stock
1 mL x 10 mM (in DMSO)$157In Stock
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Purity:99.94%
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Product Introduction

Bioactivity
Description
ML254 competitively interacts with the MPEP allosteric binding site. ML254 is highly selective for mGlu5 versus other mGlu receptors, has a clean ancillary Ricerca profile, and suitable dystrophia myotonica protein kinase (DMPK) properties for systemic dosing in rodents.
Targets&IC50
mGluR5 (rat):8.03 nM (pEC50), mGluR5 (rat):9.3 nM (EC50)
Chemical Properties
Molecular Weight310.32
FormulaC18H15FN2O2
Cas No.1428630-86-7
SmilesCC1(COC1)NC(=O)c1ccc(cn1)C#Cc1cccc(F)c1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (88.62 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2225 mL16.1124 mL32.2248 mL161.1240 mL
5 mM0.6445 mL3.2225 mL6.4450 mL32.2248 mL
10 mM0.3222 mL1.6112 mL3.2225 mL16.1124 mL
20 mM0.1611 mL0.8056 mL1.6112 mL8.0562 mL
50 mM0.0644 mL0.3222 mL0.6445 mL3.2225 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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