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MUT056399

Catalog No. T12126   CAS 1269055-85-7
Synonyms: Fab-001

MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli (IC50s of 12 nM and 58 nM, respectively).

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MUT056399 Chemical Structure
MUT056399, CAS 1269055-85-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 80.00
5 mg In stock $ 197.00
10 mg In stock $ 328.00
25 mg In stock $ 553.00
50 mg In stock $ 789.00
100 mg In stock $ 1,070.00
1 mL * 10 mM (in DMSO) In stock $ 217.00
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Purity: 99.91%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli (IC50s of 12 nM and 58 nM, respectively).
Targets&IC50 S. aureus:12 nM , for E. coli:58 nM
In vitro MUT056399 is a highly potent new inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli.?In vitro, MUT056399 was very active against S. aureus strains, including methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), linezolid-resistant, and multidrug-resistant strains, with MIC(90)s between 0.03 and 0.12 μg/ml.?MUT056399 was also active against coagulase-negative staphylococci, with MIC(90)s between 0.12 and 4 μg/ml.?The antibacterial spectrum is consistent with specific FabI inhibition with no activity against bacteria using FabK but activity against FabI-containing Gram-negative bacilli.?In vitro, resistant clones of S. aureus were obtained at a low frequency.?All of the resistant clones analyzed were found to contain mutations in the fabI gene[1].
In vivo In vivo, MUT056399, administered subcutaneously, protected mice from a lethal systemic infection induced by MSSA, MRSA, and vancomycin-intermediate S. aureus strains (50% effective doses ranging from 19.3 mg/kg/day to 49.6 mg/kg/day).?In the nonneutropenic murine thigh infection model, the same treatment with MUT056399 reduced the bacterial multiplication of MSSA and MRSA in the thighs of immunocompetent mice[1]
Synonyms Fab-001
Molecular Weight 293.27
Formula C15H13F2NO3
CAS No. 1269055-85-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (102.29mM)

TargetMolReferences and Literature

1. Escaich S, et al. The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7. 2. Schiebel J, et al. An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognitionand reduction. Biochemistry. 2015 Mar 17;54(10):1943-55.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Bacterial Compound Library Bioactive Compounds Library Max ReFRAME Related Library Anti-Infection Compound Library Inhibitor Library Bioactive Compound Library NO PAINS Compound Library

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Keywords

MUT056399 1269055-85-7 Microbiology/Virology Antibacterial Inhibitor inhibit Bacterial Fab 001 Fab-001 Fab001 MUT-056399 MUT 056399 inhibitor

 

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