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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 g | $50 | In Stock |
Description | Methionine (D-Methionine) (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation. |
In vitro | When human plasma is incubated with Methionine (D-methionine) and CP, a Pt-D-methionine complex forms, regardless of the sequence in which they are added. Initially, an early CP hydrolysis product combines with Methionine to create a 1:1 complex, which subsequently leads to a 2:1 compound over time. These Pt-D-methionine compounds are crucial in how Methionine shields mammalian organisms from CP-induced toxicities[2]. |
In vivo | Administration of Methionine (D-methionine) concurrently with cisplatin results in a cell density of 0.8±0.070 (SEM), which is significantly higher than that observed in rats receiving cisplatin alone (P<0.01), yet comparable to control groups and those treated with D-methionine only (P>0.05). Solo administration of Methionine yields an average cell density of 0.95±0.099 (SEM), also showing no significant difference from controls (P>0.05)[3]. |
Alias | D-Methionine, MRX-1024 |
Molecular Weight | 149.21 |
Formula | C5H11NO2S |
Cas No. | 348-67-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 22.5 mg/mL (150.8 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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