Home Tools
Log in
Cart

Mitotane

Catalog No. T1199   CAS 53-19-0
Synonyms: Mitotan, o,p'-DDD, NCI-C04933, 2,4′-DDD

Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Mitotane Chemical Structure
Mitotane, CAS 53-19-0
Pack Size Availability Price/USD Quantity
50 mg In stock $ 30.00
100 mg In stock $ 42.00
200 mg In stock $ 58.00
500 mg In stock $ 89.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 98%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Synonyms Mitotan, o,p'-DDD, NCI-C04933, 2,4′-DDD
Molecular Weight 320.04
Formula C14H10Cl4
CAS No. 53-19-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 60 mg/mL (187.5 mM)

Ethanol: 60 mg/mL (187.5 mM)

TargetMolReferences and Literature

1. Zatelli MC, et al. Endocrinology,2010, 151(6), 2453-2561. 2. Lin CW, et al. Toxicology,2012, 298(1-3), 14-23. 3. Germano A, et al. Mol Cell Endocrinol. 2014 Jan 25;382(1):1-7. 4. Martz F, et al. Res Commun Chem Pathol Pharmacol,1976, 13(1), 83-92.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Tobacco Monomer Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Antidepressant Compound Library FDA-Approved Drug Library Neurotransmitter Receptor Compound Library Apoptosis Compound Library ReFRAME Related Library

Related Products

Related compounds with same targets
bPiDDB MHP 133 Vesamicol hydrochloride N-Desmethylclozapine AChE/BChE-IN-10 Adenine Disopyramide Glycopyrrolate

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mitotane 53-19-0 Apoptosis Neuroscience AChR drug-drug interactions cholesterol inhibit Inhibitor antineoplastic Mitotan HepaRG o,p'-DDD corticotroph cells NCI-C04933 2,4′-DDD adrenocortical carcinoma TαT1 H295R NCI-C 04933 NCI-C-04933 inhibitor

 

TargetMol