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NAMI-A

Catalog No. T16266 CAS 201653-76-1

NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.

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NAMI-A, CAS 201653-76-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 47.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 172.00
25 mg	In stock	$ 373.00
50 mg	In stock	$ 686.00
100 mg	In stock	$ 987.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.

In vitro

NAMI-A can significantly affect tumor cells with metastatic ability. The half-life of NAMI-A elimination from the lungs is longer than for the liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations.[1]
The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397.[2]

Molecular Weight	458.18
Formula	C8H15Cl4N4ORuS
CAS No.	201653-76-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 8.28 mg/mL (18.07 mM), Sonification and heating are recommended.

References and Literature

1. Sava G et al. Dual Action of NAMI-A in inhibition of solid tumor metastasis: selective targeting of metastatic cells and binding to collagen. Clin Cancer Res. 2003 May;9(5):1898-905. 2. Pelillo C et al. Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. J Inorg Biochem. 2016 Jul;160:225-35.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Masitinib mesylate Defactinib hydrochloride Excisanin A ALK inhibitor 1 GSK2256098 Masitinib NVP-TAE 226 FAK inhibitor 2

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Keywords

NAMI-A 201653-76-1 Angiogenesis Cytoskeletal Signaling Metabolism Tyrosine Kinase/Adaptors FAK CETP NAMIA NAMI A inhibitor inhibit

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