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ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $77 | In Stock | |
5 mg | $197 | In Stock | |
10 mg | $322 | In Stock | |
25 mg | $547 | In Stock | |
50 mg | $788 | In Stock | |
100 mg | $1,080 | In Stock | |
1 mL x 10 mM (in DMSO) | $247 | In Stock |
Description | ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively. |
Targets&IC50 | ACC2 (human):4.1 nM , ACC1 (human):3.5 nM |
In vivo | ND-646-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo.?Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth.?When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC. |
Molecular Weight | 568.64 |
Formula | C28H32N4O7S |
Cas No. | 1434639-57-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 95 mg/mL (167.06 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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