Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2(IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 77.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 322.00 | |
25 mg | In stock | $ 547.00 | |
50 mg | In stock | $ 788.00 | |
100 mg | In stock | $ 1,080.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 247.00 |
Description | ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2(IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively) |
Targets&IC50 | ACC2 (human):4.1 nM , ACC1 (human):3.5 nM |
In vivo | ND-646-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo.?Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth.?When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC. |
Molecular Weight | 568.64 |
Formula | C28H32N4O7S |
CAS No. | 1434639-57-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (167.06 mM)
You can also refer to dose conversion for different animals. More
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ND-646 1434639-57-2 Metabolism Acetyl-CoA Carboxylase ND 646 ACC, Acetyl Coenzyme A Carboxylase Inhibitor inhibit ND646 inhibitor