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ND-646

Catalog No. TQ0243Cas No. 1434639-57-2

ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

ND-646

ND-646

Purity: 98.64%
Catalog No. TQ0243Cas No. 1434639-57-2
ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.
Pack SizePriceAvailabilityQuantity
1 mg$77In Stock
5 mg$197In Stock
10 mg$322In Stock
25 mg$547In Stock
50 mg$788In Stock
100 mg$1,080In Stock
1 mL x 10 mM (in DMSO)$247In Stock
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Purity:98.64%
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Product Introduction

Bioactivity
Description
ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.
Targets&IC50
ACC2 (human):4.1 nM , ACC1 (human):3.5 nM
In vivo
ND-646-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo.?Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth.?When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC.
Chemical Properties
Molecular Weight568.64
FormulaC28H32N4O7S
Cas No.1434639-57-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 95 mg/mL (167.06 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7586 mL8.7929 mL17.5858 mL87.9291 mL
5 mM0.3517 mL1.7586 mL3.5172 mL17.5858 mL
10 mM0.1759 mL0.8793 mL1.7586 mL8.7929 mL
20 mM0.0879 mL0.4396 mL0.8793 mL4.3965 mL
50 mM0.0352 mL0.1759 mL0.3517 mL1.7586 mL
100 mM0.0176 mL0.0879 mL0.1759 mL0.8793 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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