Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts. NKH477 directly activates the catalytic unit of adenylate cyclase and enhances intracellular cAMP .
Description | NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts. NKH477 directly activates the catalytic unit of adenylate cyclase and enhances intracellular cAMP . |
In vivo | NKH477 (p.o.; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner. |
Synonyms | Colforsin dapropate hydrochloride |
Molecular Weight | 546.09 |
Formula | C27H44ClNO8 |
CAS No. | 138605-00-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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NKH477 138605-00-2 Neuroscience NMDAR NKH-477 NKH 477 Colforsin dapropate Hydrochloride Colforsin dapropate hydrochloride inhibitor inhibit