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NRA-0160
NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)
Catalog No. T12252Cas No. 204718-47-8
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NRA-0160
Catalog No. T12252Cas No. 204718-47-8
NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM) |
| Targets&IC50 | 5-HT2A receptor:180 nM (Ki, in rat), D3 receptor:39 nM (ki), D4 receptor:0.48 nM (ki), α1-adrenoceptor (rat):237 nM (ki) |
| In vivo | NRA0160 dose-dependently and significantly reverses the effects of MAP on both A9 and Al0 dopamine neurons.?NRA0160 is slightly more potent in reversiig the effects of MAP on A10 (ED50 = 1.0 mg/kg) than on A9 dopamine neurons (ED50 = 1.3 mg/kg).?NRA0160 reverses the effect of AP0 on both A9 and A10 dopamine neurons.?ED50 values for the effects of NRA0160 on APO-induced inhibition of A9 and A10 dopamine neurons are 1.3 mg/kg and 0.5 mg/kg, respectively[2]. |
| Molecular Weight | 439.52 |
| Formula | C24H23F2N3OS |
| Cas No. | 204718-47-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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