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OMDM-1

Catalog No. T12302   CAS 616884-62-9
Synonyms: (Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide

OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM.

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OMDM-1 Chemical Structure
OMDM-1, CAS 616884-62-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 197.00
5 mg In stock $ 456.00
10 mg In stock $ 668.00
25 mg In stock $ 1,060.00
50 mg In stock $ 1,420.00
100 mg In stock $ 1,920.00
500 mg In stock $ 3,850.00
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Purity: 97.88%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM.
Targets&IC50 anandamide cellular uptake(ki):2.4 μM(Ki)
In vitro OMDM-1 is anovel potent and selective inhibitors of ACU?and one 'hybrid' agonist of CB(1) and VR1 receptors (OMDM-6).?Unlike other compounds of the same type, OMDM-1, OMDM-2, and OMDM-6 were very stable to enzymatic hydrolysis by rat brain homogenates.The (R)- and, particularly, the (S)-1'-(4-hydroxybenzyl) derivatives of N-oleoylethanolamine and AEA (OMDM-1, OMDM-2, OMDM-3, and OMDM-4) inhibited to a varied extent ACU in RBL-2H3 cells (K(i) ranging between 2.4 and 17.7 micro M), the oleoyl analogues (OMDM-1 and OMDM-2, K(i) 2.4 and 3.0 micro M, respectively) being 6- to 7-fold more potent than the arachidonoyl analogues (OMDM-3 and OMDM-4). [1].
Synonyms (Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide
Molecular Weight 431.65
Formula C27H45NO3
CAS No. 616884-62-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 30mg/ml

dimethyl formamide: 30mg/ml

DMSO: 55 mg/mL (127.42 mM)

TargetMolReferences and Literature

1. Ortar G, et al. Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochem Pharmacol. 2003 May 1;65(9):1473-81.

Related compound libraries

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Keywords

OMDM-1 616884-62-9 Metabolism Endogenous Metabolite vanilloid cells CB1 receptor type RBL-2H3 uptake FAAH cannabinoid (Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide VR1 inhibit Inhibitor CB2 OMDM1 acids fatty OMDM 1 inhibitor

 

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