Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain and effectively inhibits Pin1 cis-trans isomerizing activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 82.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 374.00 | |
25 mg | In stock | $ 535.00 | |
50 mg | In stock | $ 773.00 | |
100 mg | In stock | $ 997.00 | |
200 mg | In stock | $ 1,460.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 167.00 |
Description | PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain and effectively inhibits Pin1 cis-trans isomerizing activity. |
Targets&IC50 | Pin1:72.3 nM |
In vitro | PIN1 inhibitor API-1 significantly suppresses SK-Hep-1, SNU-423, and Hep3B cell proliferation (IC50=0.683-4.16 μM)[1]. |
In vivo | PIN1 inhibitor API-1 inhibits tumor growth by up-regulating mature miRNA biogenesis in mice [1]. |
Molecular Weight | 366.3 |
Formula | C15H13F3N6O2 |
CAS No. | 680622-70-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (682.50 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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PIN1 inhibitor API-1 680622-70-2 Others Inhibitor MicroRNA PIN1 inhibitor API 1 PIN1 inhibitor API1 inhibit PIN-1 inhibitor API-1 miRNA inhibitor