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Pipobroman

Catalog No. T4570 CAS 54-91-1

Synonyms: Vercyte, A-8103, Amedel

Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, within 3 months, to attain a response in more than 90% of patients, without clinically relevant toxicities. The 10-years risk of thrombosis of patients treated with Pipobroman is about 15%, The anti-proliferative activity of Pipobroman on bone marrow megakaryocytes seems of particular value in lowering the occurrence of post-PV and post-ET MMM, whose risk is the lowest registered with available treatments. The 10-year risk of acute leukemia with Pipobroman is 5% in PVand 3% in ET, which is only slightly higher than that expected as a natural evolution of the disease. In conclusion, the use of Pipobroman is a definite alternative to hydroxyurea in patients with PV and ET at high risk of thrombosis.

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Pipobroman, CAS 54-91-1

Pack Size	Availability	Price/USD
50 mg	In stock	$ 58.00
100 mg	In stock	$ 81.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 93.01%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Vercyte, A-8103, Amedel
Molecular Weight	356.05
Formula	C10H16Br2N2O2
CAS No.	54-91-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (168.51 mM)

H2O: Insoluble

References and Literature

1. Passamonti F, et al. Treatment of polycythemia vera and essential thrombocythemia: the role of pipobroman. Leuk Lymphoma. 2003 Sep;44(9):1483-1488.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Tyrosine Kinase Inhibitor Library Inhibitor Library Hematopoietic Toxicity Compound Library FDA-Approved Drug Library Drug-induced Liver Injury (DILI) Compound Library Human Metabolite Library

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Related compounds with same targets

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Keywords

Pipobroman 54-91-1 DNA Damage/DNA Repair Others DNA Alkylator/Crosslinker Vercyte Inhibitor MDS AML A 8103 myeloproliferative neoplasm A-8103 thrombosis Amedel Polycythemia vera A8103 inhibit cutaneous squamous cell carcinoma inhibitor

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