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Progesterone

Catalog No. T0478 CAS 57-83-0

Synonyms: Pregn-4-ene-3,20-dione

Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production.

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Progesterone, CAS 57-83-0

Pack Size	Availability	Price/USD
50 mg	In stock	$ 38.00
100 mg	In stock	$ 54.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.89%

Purity: 99.86%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production.
In vitro	Twenty-one days after dorsal medial thalamic nuclei damage, rats treated with progesterone exhibited reduced neuronal degeneration. In female 3xTg-AD mice, progesterone negated the advantageous effects against Abeta accumulation, yet it did not affect behavioral performance. During the Morris water maze spatial navigation task, progesterone-treated rats demonstrated less impairment compared to control rats.
In vivo	Progesterone drives a series of events in which luminal cells may furnish basal cells with Wnt4 and RANKL signals, which in turn respond by upregulating homologous receptors, transcriptional targets, and markers of the cell cycle. Progesterone exhibits a biphasic effect on the proliferation of breast cancer cells; it stimulates growth during the initial cell cycle and subsequently impedes cell progression at the G1/S phase.

Synonyms	Pregn-4-ene-3,20-dione
Molecular Weight	314.46
Formula	C21H30O2
CAS No.	57-83-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 31.5 mg/mL (100 mM)

DMSO: 31.5 mg/mL (100 mM)

References and Literature

1. Owen GI, et al. J Biol Chem,1998, 273(17), 10696-10701. 2. Joshi PA, et al. Nature,2010, 465(7299), 803-807. 3. Bitran D, et al. Pharmacol Biochem Behav,1993, 45(2), 423-428. 4. Carroll JC, et al. J Neurosci,2007, 27(48), 13357-13365. 5. Roof RL, et al. Exp Neurol,1994, 129(1), 64-69. 6. Wang D, Jin M, Zhou Y, et al. Loss of miR-29a Impairs Decidualisation of Endometrial Stromal Cells by Enhancing TET3 Binding to the Col1A1 Promoter[J]. Available at SSRN 3797277. 7. Zhang S, Sun C, Zhao S, et al. Exposure to DEHP or its metabolite MEHP promotes progesterone secretion and inhibits proliferation in mouse placenta or JEG-3 cells[J]. Environmental Pollution. 2020, 257: 113593. 8. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.

Citations

1. Sun C C, Zhao S, Chu L L, et al. Di (2-ethyl-hexyl) Phthalate Disrupts Placental Growth in a Dual Blocking Mode. Journal of Hazardous Materials. 2021: 126815 2. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks. Chemical Science. 2020, 11(7): 1775-1797. 3. Lin H, Lan K C, Ou Y C, et al. Highly Expressed Progesterone Receptor B Isoform Increases Platinum Sensitivity and Survival of Ovarian High-Grade Serous Carcinoma. Cancers. 2021, 13(21): 5578. 4. Wang D, Jin M, Zhou Y, et al. Loss of miR-29a Impairs Decidualisation of Endometrial Stromal Cells by Enhancing TET3 Binding to the Col1A1 Promoter. iScience. 2021 24 September 5. Zhang S, Sun C, Zhao S, et al. Exposure to DEHP or its metabolite MEHP promotes progesterone secretion and inhibits proliferation in mouse placenta or JEG-3 cells. Environmental Pollution. 2020, 257: 113593 6. Cui L, Xu F, Xu C, et al.Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis.Journal of Biomedical Science.2022, 29(1): 1-14. 7. Zhao W, Xu C, Peng L, et al.cAMP/PKA signaling promotes AKT deactivation by reducing CIP2A expression, thereby facilitating decidualization.Molecular and Cellular Endocrinology.2023: 111946.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Tobacco Monomer Library GPCR Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Human Endogenous Metabolite Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Covalent Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Progesterone 57-83-0 Endocrinology/Hormones GPCR/G Protein Metabolism Neuroscience Others Opioid Receptor Endogenous Metabolite Progesterone Receptor Estrogen/progestogen Receptor NR3C3 Pregn-4-ene-3,20-dione inhibit Inhibitor inhibitor

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