Shopping Cart
- Remove All
Your shopping cart is currently empty
QO-40
QO-40 is a KCNQ2/3 potassium channels activator.
Catalog No. T8446Cas No. 1259536-70-3
Select Batch
Purity:99.57%
Contact us for more batch information
QO-40
Catalog No. T8446Cas No. 1259536-70-3
QO-40 is a KCNQ2/3 potassium channels activator.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $38 | In Stock | |
| 25 mg | $71 | In Stock | |
| 50 mg | $107 | In Stock | |
| 100 mg | $163 | In Stock | |
| 200 mg | $238 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $43 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "QO-40"
Indapamide
Veroxil, Noranat, Tertensif
T149826807-65-8
Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
Inquiry
Minoxidil sulfate
Minoxidil sulphate, U-58838
T813583701-22-8
Minoxidil sulfate (U-58838) is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil.
- $31
Size
QTY
Halothane
Narcotane, Anestan
T0954151-67-7
Halothane (Anestan) is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required.
- $45
Size
QTY
Cloperastine hydrochloride
HT-11 hydrochloride
T072314984-68-0
Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.
- $31
Size
QTY
2,2,2-Trichloroethanol
T37709115-20-8
2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4). It activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery [1]. [1]. Nikhil K Parelkar, et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332(3):803-10.
- $29
Size
QTY
Tetraethylammonium bromide
TEAB, TEA bromide
T836171-91-0
Tetraethylammonium bromide (TEA bromide) can selectively block potassium channels.
- $30
Size
QTY
Butamben
Butyl 4-aminobenzoate
T091694-25-7
Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
- $31
Size
QTY
(±)-Naringenin
Cited
Salipurpol, Naringenine, Naringenin
TMS217167604-48-2
(±)-Naringenin (Naringenine) is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
- $45
Size
QTY
CitedQuinine
T0690130-95-0
Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances of hypersensitivity reactions which can be accompanied by hepatitis and mild jaundice.
- $39
Size
QTY
Tolbutamide Cited
HLS 831
T105464-77-7
Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
- $41
Size
QTY
CitedTetraethylammonium chloride
T753856-34-8
Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties.
- $31
Size
QTY
Chlorzoxazone Cited
Paraflex, Chlorzoxazon
T165095-25-0
Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.
- $30
Size
QTY
CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | QO-40 is a KCNQ2/3 potassium channels activator. |
| In vitro | QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction.?The V(1/2) was negatively shifted in a concentration-dependent manner.?The compounds markedly slowed both KCNQ2/3 channel activation and deactivation kinetics. |
| Molecular Weight | 377.75 |
| Formula | C18H11ClF3N3O |
| Cas No. | 1259536-70-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (66.18 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy QO-40 | purchase QO-40 | QO-40 cost | order QO-40 | QO-40 chemical structure | QO-40 in vitro | QO-40 formula | QO-40 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.