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Qingyangshengenin B

Catalog No. TMS1461 CAS 106758-54-7

Synonyms: Otophylloside B

Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic and anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer's disease. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish.

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Qingyangshengenin B, CAS 106758-54-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 196.00
10 mg	In stock	$ 295.00
25 mg	In stock	$ 497.00
50 mg	In stock	$ 723.00
100 mg	In stock	$ 987.00

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Purity: 99.26%

Purity: 98.56%

Biological Description

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Description	Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic and anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer's disease. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish.
In vitro	Otophylloside B (Ot B)?could modestly extend the lifespan of C. elegans, delay the age-related decline of body movement and improve the stress resistance.?Further investigating the molecular mechanism of lifespan extension effect revealed that Ot B could activate the FOXO transcription factor DAF-16.?Ot B could not further extend the lifespan of long-lived mutant of insulin/IGF-1-like receptor (daf-2).?In addition, Ot B also requires SIR-2.1 and CLK-1 which is an enzyme in ubiquinone synthesis, for lifespan extension.
Source	Natural Products > Asclepiadaceae > Cynanchum

Synonyms	Otophylloside B
Molecular Weight	923.13
Formula	C49H78O16
CAS No.	106758-54-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (5.42 mM)

References and Literature

1. Yang, Jie, Wan, et al. The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans[J]. Natural Products and Bioprospecting, 2015, 5(4):177-183.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Anti-Aging Compound Library Selected Plant-Sourced Compound Library Natural Product Library Anti-Alzheimer's Disease Compound Library NO PAINS Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Covalent Inhibitor Library

Related Products

Related compounds with same targets

Geniposide BSBM7 LX2343 PBD-150 Ginsenoside Rg1 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine β-amyloid 1-11 acetate(190436-05-6 free base) BACE1-IN-5

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Keywords

Qingyangshengenin B 106758-54-7 Neuroscience Beta Amyloid Amyloid-β Abeta Inhibitor β-amyloid peptide Otophylloside B inhibit inhibitor

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