Powder: -20°C for 3 years | In solvent: -80°C for 1 year
R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 137.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 475.00 | |
100 mg | In stock | $ 678.00 | |
500 mg | In stock | $ 1,380.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 85.00 |
Description | R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor. |
In vitro | R162 decreased intracellular fumarate levels attenuated GPx activity by inhibited GDH1 activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells. R162 inhibits tumor growth potential and cell proliferation of human cancer cells. |
In vivo | In xenograft tumor mouse models, R162 (30 mg/kg/day, i.p.) does not cause a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties. Compared with control mice, R162 (20 mg/kg/day) markedly decreases tumor growth and masses and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice. |
Molecular Weight | 264.28 |
Formula | C17H12O3 |
CAS No. | 64302-87-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
R162 64302-87-0 Metabolism Dehydrogenase inhibit Inhibitor R 162 R-162 inhibitor