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S-Methylisothiourea sulfate

Catalog No. T22419 CAS 867-44-7

Synonyms: (S)-Methylisothiourea sulfate

S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1].

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S-Methylisothiourea sulfate Chemical Structure

S-Methylisothiourea sulfate, CAS 867-44-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 39.00
50 mg	In stock	$ 55.00
100 mg	In stock	$ 80.00
500 mg	In stock	$ 197.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1].
In vitro	S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site. The effect of S-Methylisothiourea sulfate on iNOS activity can be reversed by excess L-arginine in a concentration-dependent manner. S-Methylisothiourea sulfate (up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase. S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages. S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1].
In vivo	S-Methylisothiourea sulfate dose-dependently reverses (0.01-3 mg/kg) the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin [bacterial lipopolysaccharide (LPS), 10 mg/kg, i.v.] in anesthetized rats. Moreover, therapeutic administration of S-Methylisothiourea sulfate (5 mg/kg, i.p., given 2 hr after LPS, 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS. S-Methylisothiourea sulfate (1 mg/kg, i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg, i.p.)[1].
Animal Research	S-Methylisothiourea sulfate (Male Wistar rats (260-320 g); 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg; Intravenous injection) caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats and also inhibited iNOS activity measured in homogenates of lung[1].

Synonyms	(S)-Methylisothiourea sulfate
Molecular Weight	139.18
Formula	C2H6N2S·1/2H2O4S
CAS No.	867-44-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 60 mg/mL (431.09 mM), Sonification is recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Balter-Seri J, et al. Infect Immun. 1999, 67(12):6364-8. 2. Szabó C, et al. Proc Natl Acad Sci U S A. 1994, 91(26):12472-6. 3. Afulukwe IF, et al. Am J Respir Crit Care Med. 2000, 162(1):21-6.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Bioactive Compound Library Anti-Infection Compound Library Anti-Viral Compound Library Anti-Aging Compound Library NO PAINS Compound Library

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Keywords

S-Methylisothiourea sulfate 867-44-7 Immunology/Inflammation Microbiology/Virology NOS NO Synthase HSV septic (S)-Methylisothiourea sulfate S-Methylisothiourea blood Methylisothiourea Sulfate S-Methylisothiourea Sulfate shock iNOS Nitric oxide synthases SMethylisothiourea sulfate Inhibitor Herpes simplex virus inhibit S Methylisothiourea sulfate hypotension pressure circulatory inhibitor

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