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SB-209670
🥰Excellent
Catalog No. T34541Cas No. 157659-79-5
Alias SB 209670
SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
SB-209670
🥰Excellent
Purity: 99.24%
Catalog No. T34541Alias SB 209670Cas No. 157659-79-5
SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 332 € | In Stock | |
| 5 mg | 786 € | In Stock | |
| 10 mg | 1.073 € | In Stock | |
| 25 mg | 1.510 € | In Stock | |
| 50 mg | 1.881 € | In Stock | |
| 100 mg | 2.375 € | In Stock | |
| 500 mg | 4.655 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 796 € | In Stock |
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Purity:99.24%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle. |
| In vivo | SB 209670 (3 mg kg-1, i.v. bolus + 100 micrograms kg-1, i.v. infusion commencing 15 min prior to LPS ; rats) significantly augmented the hypotension as well as the vascular hyporeactivity to NA caused by endotoxaemia.[5] SB 209670 (3 mg kg-1, i.v. bolus given 15 min prior to LPS ; LPS-rats) resulted in a reduction in 6 h-survival from 71% (control) to 30% and 13%, respectively.[5] SB 209670 (3 mg kg-1, i.v. bolus 15 min prior to LPS ; rats) significantly augmented the serum levels of creatinine, bilirubin, GPT and GOT caused by endotoxin.[5] SB 209670 (3 mg kg-1, i.v. bolus ; rats) significantly augmented the metabolic acidosis caused by LPS.[5] |
| Alias | SB 209670 |
| Molecular Weight | 520.53 |
| Formula | C29H28O9 |
| Cas No. | 157659-79-5 |
| Smiles | C(O)(=O)[C@H]1[C@@H](C=2C([C@@H]1C=3C=C4C(=CC3)OCO4)=CC=C(OCCC)C2)C5=C(OCC(O)=O)C=C(OC)C=C5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 27.5 mg/mL (52.83 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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