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SB-209670

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Purity:99.24%

ee:100%

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COA HNMR HPLC LCMS CSFC ORP

SB-209670

Catalog No. T34541Cas No. 157659-79-5

SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.

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Pack Size	Price	Availability
1 mg	$350	In Stock
5 mg	$828	In Stock
10 mg	$1,130	In Stock
25 mg	$1,590	In Stock
50 mg	$1,980	In Stock
100 mg	$2,500	In Stock
500 mg	$4,900	In Stock
1 mL x 10 mM (in DMSO)	$838	In Stock

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Product Introduction

Bioactivity

Description	SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
In vivo	SB 209670 (3 mg kg-1, i.v. bolus + 100 micrograms kg-1, i.v. infusion commencing 15 min prior to LPS ; rats) significantly augmented the hypotension as well as the vascular hyporeactivity to NA caused by endotoxaemia.[5] SB 209670 (3 mg kg-1, i.v. bolus given 15 min prior to LPS ; LPS-rats) resulted in a reduction in 6 h-survival from 71% (control) to 30% and 13%, respectively.[5] SB 209670 (3 mg kg-1, i.v. bolus 15 min prior to LPS ; rats) significantly augmented the serum levels of creatinine, bilirubin, GPT and GOT caused by endotoxin.[5] SB 209670 (3 mg kg-1, i.v. bolus ; rats) significantly augmented the metabolic acidosis caused by LPS.[5]
Alias	SB 209670

Chemical Properties

Molecular Weight	520.53
Formula	C29H28O9
Cas No.	157659-79-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (52.83 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9211 mL	9.6056 mL	19.2112 mL	96.0559 mL
5 mM	0.3842 mL	1.9211 mL	3.8422 mL	19.2112 mL
10 mM	0.1921 mL	0.9606 mL	1.9211 mL	9.6056 mL
20 mM	0.0961 mL	0.4803 mL	0.9606 mL	4.8028 mL
50 mM	0.0384 mL	0.1921 mL	0.3842 mL	1.9211 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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