Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 110.00 | |
5 mg | 35 days | $ 295.00 | |
10 mg | 35 days | $ 483.00 | |
25 mg | 35 days | $ 1,060.00 |
Description | SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
Targets&IC50 | 5-HT1D receptor:5.9(pki), D2 receptor:6 (pki), 5-HT1B receptor:<5.2 (pki), D3 receptor:pki: 8.0 |
In vitro | SB-277011 dihydrochloride is a selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor, and restores ≥100-fold selectivity against the D2, 5-HT1B, and 5-HT1D receptors(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
In vivo | the effects of quinelorane in the nucleus accumbens completely reversed by SB-277011 dihydrochloride (SB 277011; 3 mg/kg, p.o.), but does not reverse the effects of quinelorane in the striatum at 93 mg/kg in rats. |
Synonyms | SB-277011A dihydrochloride |
Molecular Weight | 511.49 |
Formula | C28H32Cl2N4O |
CAS No. | 1226917-67-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SB-277011 dihydrochloride 1226917-67-4 GPCR/G Protein Neuroscience Dopamine Receptor SB-277011A SB-277011 SB277011 Dihydrochloride SB-277011A Dihydrochloride SB277011 dihydrochloride SB-277011 Dihydrochloride SB277011 SB 277011 Dihydrochloride SB-277011A dihydrochloride SB 277011 dihydrochloride SB 277011 inhibitor inhibit