SCH 563705

Name: SCH 563705
Brand: TargetMol
SKU: T16864
Price: 2270 USD
Availability: InStock
Rating: 5 (10 reviews)

SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).

Catalog No. T16864Cas No. 473728-58-4

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SCH 563705

Catalog No. T16864Cas No. 473728-58-4

SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
25 mg	$2,270	In Stock
50 mg	$2,980	In Stock
100 mg	$4,000	In Stock

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Product Introduction

Bioactivity

Description	SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
Targets&IC50	CXCR2 (mouse):5.2 nM, CXCR1:3 nM （ki）, CXCR1:7.3 nM, CXCR2:1 nM （ki）, CXCR2:1.3 nM
In vitro	SCH 563705 potently inhibits mouse CXCR2 (IC50 = 5.2 nM). SCH 563705 displays potent inhibition against both Gro-a and IL-8 induced human neutrophil migration (chemotaxis IC50 = 0.5 nM, against 30 nM of Gro-a; chemotaxis IC50 = 37 nM, against 3 nM of IL-8) [1][2].
In vivo	SCH 563705 exhibits favorable oral pharmacokinetic profiles in rats, mice, monkeys, and dogs. Treatment with SCH 563705 (3-30 mg/kg p.o) leads to a dose-dependent increase in plasma CXCL1 levels. Additionally, SCH 563705 (50 mg/kg p.o) reduces blood Ly6G+ Ly6C+ neutrophil frequency without altering Ly6GLy6Chi monocyte levels [1][2].

Chemical Properties

Molecular Weight	425.48
Formula	C₂₃H₂₇N₃O₅
Cas No.	473728-58-4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 30 mg/mL (70.51 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3503 mL	11.7514 mL	23.5029 mL	117.5143 mL
5 mM	0.4701 mL	2.3503 mL	4.7006 mL	23.5029 mL
10 mM	0.2350 mL	1.1751 mL	2.3503 mL	11.7514 mL
20 mM	0.1175 mL	0.5876 mL	1.1751 mL	5.8757 mL
50 mM	0.0470 mL	0.2350 mL	0.4701 mL	2.3503 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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