Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM, respectively). |
Targets&IC50 | D5:0.3 nM (Ki), D1:0.2 nM (Ki), GIRK:268 nM, 5-HT2C:9.3 nM (Ki) |
In vitro | SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway[4].SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. |
In vivo | SCH-23390 can eliminate systemic seizures caused by chemical convulsions:pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated(psychosis and Parkinson's disease). Apart from the study of neurological disorders, SCH-23390 has been wildly used as a tool in the topographical determination of brain D1 receptors in rodents, nonhuman primates, and humans[1]. SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat[1]. SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions[5]. |
Synonyms | R-(+)-SCH-23390 maleate |
Molecular Weight | 403.86 |
Formula | C21H22ClNO5 |
CAS No. | 87134-87-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SCH-23390 maleate 87134-87-0 GPCR/G Protein Membrane transporter/Ion channel Neuroscience 5-HT Receptor Potassium Channel Dopamine Receptor constriction R-SCH-23390 Maleate SCH 23390 Maleate 5‐HT1C SCH 23390 DA1-like GIRK SCH 23390 maleate ductus SCH-23390 D5-receptor inhibit SCH23390 R-SCH23390 Maleate neurological SCH23390 Maleate SCH23390 maleate Inhibitor 5-hydroxytryptamine Receptor KcsA R-(+)-SCH-23390 maleate enantioselective 5‐HT2 Serotonin Receptor epileptiform SCH-23390 Maleate R-SCH 23390 Maleate inhibitor