Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 629.00 | |
50 mg | In stock | $ 896.00 | |
100 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 272.00 |
Description | SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway. |
Targets&IC50 | SIRT7:325 nM |
In vitro | SIRT7 inhibitor 97491 (1-10 μM) effectively reduces the proliferation of human uterine sarcoma MES-SA cells without exhibiting cytotoxic effects on HEK293 human embryonic kidney cells[1]. Specifically, when applied at concentrations of 1, 5, and 10 μM for 72 hours, it resulted in a greater than 50% decrease in proliferation of MES-SA cells at the 5 and 10 μM concentrations. Conversely, the same concentrations did not significantly affect the viability of HEK293 cells after 24 hours of exposure, indicating selective action. |
In vivo | The SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) effectively suppresses tumor growth in xenograft mice[1]. Utilizing Balb/c nude mice (18-20 g; 6-8 weeks old) implanted with MES-SA cells[1], the dosage administered was 2 mg/kg via intraperitoneal injection over a three-week period, excluding weekends. The outcome was a significant inhibition of cancer growth in vivo. |
Molecular Weight | 285.73 |
Formula | C15H12ClN3O |
CAS No. | 1807758-81-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 500 mg/mL (1749.90 mM)
You can also refer to dose conversion for different animals. More
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SIRT7 inhibitor 97491 1807758-81-1 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin SIRT7 inhibit p53 K373/382 tumor SIRT-7 inhibitor 97491 deacetylase Apoptosis Inhibitor inhibitor