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SJFα

Catalog No. T18681Cas No. 2254609-27-1
Alias SJFalpha, SJF α, SJF alpha

SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.

SJFα

SJFα

Catalog No. T18681Alias SJFalpha, SJF α, SJF alphaCas No. 2254609-27-1
SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.
Pack SizePriceAvailabilityQuantity
1 mg$88In Stock
5 mg$213In Stock
10 mg$396In Stock
25 mg$845In Stock
50 mg$1,490In Stock
1 mL x 10 mM (in DMSO)$498In Stock
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Product Introduction

Bioactivity
Description
SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.
Targets&IC50
p38α:7.16 nM (DC50), p38α:97.4% (Dmax), p38δ:299 nM (DC50), p38δ: 18% (Dmax)
In vitro
SJFα PROTAC (13-atom linker, amide attachment) selectively degrades p38α in MDA-MB-231 cells. SJFα degrades p38α with a DC50 = 7.16 nM and Dmax = 97.4%, but is far less effective at degrading p38δ (DC50 = 299 nM, Dmax = 18%) and does not degrade the other p38 isoforms (β and γ). [1]
AliasSJFalpha, SJF α, SJF alpha
Chemical Properties
Molecular Weight1120.27
FormulaC59H67F2N7O11S
Cas No.2254609-27-1
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL(71.41 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.8926 mL4.4632 mL8.9264 mL44.6321 mL
5 mM0.1785 mL0.8926 mL1.7853 mL8.9264 mL
10 mM0.0893 mL0.4463 mL0.8926 mL4.4632 mL
20 mM0.0446 mL0.2232 mL0.4463 mL2.2316 mL
50 mM0.0179 mL0.0893 mL0.1785 mL0.8926 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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