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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $88 | In Stock | |
5 mg | $213 | In Stock | |
10 mg | $396 | In Stock | |
25 mg | $845 | In Stock | |
50 mg | $1,490 | In Stock | |
1 mL x 10 mM (in DMSO) | $498 | In Stock |
Description | SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research. |
Targets&IC50 | p38δ:299 nM (DC50), p38δ: 18% (Dmax), p38α:7.16 nM (DC50), p38α:97.4% (Dmax) |
In vitro | SJFα PROTAC (13-atom linker, amide attachment) selectively degrades p38α in MDA-MB-231 cells. SJFα degrades p38α with a DC50 = 7.16 nM and Dmax = 97.4%, but is far less effective at degrading p38δ (DC50 = 299 nM, Dmax = 18%) and does not degrade the other p38 isoforms (β and γ). [1] |
Alias | SJFalpha, SJF α, SJF alpha |
Molecular Weight | 1120.27 |
Formula | C59H67F2N7O11S |
Cas No. | 2254609-27-1 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL(71.41 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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