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SJFα
🥰Excellent
Catalog No. T18681Cas No. 2254609-27-1
Alias SJFalpha, SJF α, SJF alpha
SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.
SJFα
🥰Excellent
Catalog No. T18681Alias SJFalpha, SJF α, SJF alphaCas No. 2254609-27-1
SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $88 | In Stock | |
| 5 mg | $213 | In Stock | |
| 10 mg | $396 | In Stock | |
| 25 mg | $845 | In Stock | |
| 50 mg | $1,490 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $498 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research. |
| Targets&IC50 | p38α:7.16 nM (DC50), p38α:97.4% (Dmax), p38δ: 18% (Dmax), p38δ:299 nM (DC50) |
| In vitro | SJFα PROTAC (13-atom linker, amide attachment) selectively degrades p38α in MDA-MB-231 cells. SJFα degrades p38α with a DC50 = 7.16 nM and Dmax = 97.4%, but is far less effective at degrading p38δ (DC50 = 299 nM, Dmax = 18%) and does not degrade the other p38 isoforms (β and γ). [1] |
| Alias | SJFalpha, SJF α, SJF alpha |
| Molecular Weight | 1120.27 |
| Formula | C59H67F2N7O11S |
| Cas No. | 2254609-27-1 |
| Smiles | C(NC1=CC(F)=C(OC=2C3=C(C=C(OCCCCOCCCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)[C@](C)(C)C)=O)C(OC)=C3)N=CC2)C=C1)(=O)C7(C(NC8=CC=C(F)C=C8)=O)CC7 |
| Relative Density. | 1.331 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL(71.41 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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