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SR10067

Catalog No. T12998Cas No. 1380548-02-6

SR10067 is a potent, selective, and brain-penetrant agonist of Rev-Erbβ (IC50 = 160 nM) and Rev-Erbα (IC50 = 170 nM) with anxiolytic activity.

SR10067

SR10067

Purity: 99.88%
Catalog No. T12998Cas No. 1380548-02-6
SR10067 is a potent, selective, and brain-penetrant agonist of Rev-Erbβ (IC50 = 160 nM) and Rev-Erbα (IC50 = 170 nM) with anxiolytic activity.
Pack SizePriceAvailabilityQuantity
1 mg$53In Stock
5 mg$136In Stock
10 mg$218In Stock
25 mg$371In Stock
50 mg$536In Stock
100 mg$693In Stock
200 mg$953In Stock
1 mL x 10 mM (in DMSO)$147In Stock
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Purity:99.88%
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Product Introduction

Bioactivity
Description
SR10067 is a potent, selective, and brain-penetrant agonist of Rev-Erbβ (IC50 = 160 nM) and Rev-Erbα (IC50 = 170 nM) with anxiolytic activity.
Targets&IC50
Rev-Erbα:170 nM , Rev-Erbβ:160 nM
Chemical Properties
Molecular Weight465.58
FormulaC31H31NO3
Cas No.1380548-02-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 65 mg/ml (139.61 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1479 mL10.7393 mL21.4786 mL107.3929 mL
5 mM0.4296 mL2.1479 mL4.2957 mL21.4786 mL
10 mM0.2148 mL1.0739 mL2.1479 mL10.7393 mL
20 mM0.1074 mL0.5370 mL1.0739 mL5.3696 mL
50 mM0.0430 mL0.2148 mL0.4296 mL2.1479 mL
100 mM0.0215 mL0.1074 mL0.2148 mL1.0739 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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