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ST-1535

ST-1535
ST 1535 is a potent and orally active antagonist of the A2A adenosine receptor, exhibiting antiparkinsonian activity and antitremorigenic effects, with potential for Parkinson’s disease research.
Catalog No. T28861Cas No. 496955-42-1
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Purity:99.64%
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ST-1535

Purity: 99.64%
Catalog No. T28861Cas No. 496955-42-1

ST 1535 is a potent and orally active antagonist of the A2A adenosine receptor, exhibiting antiparkinsonian activity and antitremorigenic effects, with potential for Parkinson’s disease research.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
5 mg$85In Stock
10 mg$117In Stock
25 mg$198In Stock
50 mg$295In Stock
100 mg$431In Stock
1 mL x 10 mM (in DMSO)$88In Stock
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Product Introduction

Bioactivity
Description
ST 1535 is a potent and orally active antagonist of the A2A adenosine receptor, exhibiting antiparkinsonian activity and antitremorigenic effects, with potential for Parkinson’s disease research.
In vitro
ST-1535 competitively antagonizes the effects of the A2A adenosine agonist NECA on cAMP in cells cloned with the human A2A adenosine receptor (IC50=353+/-30 nM), and the effects of the A1 adenosine agonist CHA on cAMP in cells cloned with the human A1 adenosine receptor (IC50=510+/-38 nM). [1]
In vivo
ST 1535, at oral doses of 5 and 10 mg/kg, antagonizes catalepsy induced by intracerebroventricular administration of the A2A adenosine agonist CGS 21680 (10 microg/5 microl) in mice. At oral doses ranging between 5 and 20 mg/kg, ST 1535 induces hypermotility and antagonizes haloperidol-induced catalepsy in mice up to 7 h. Oral ST 1535, at 1.25 and 2.5 mg/kg, potentiates L-dopa effects in reducing haloperidol-induced catalepsy. [1]
Chemical Properties
Molecular Weight272.31
FormulaC12H16N8
Cas No.496955-42-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 9 mg/mL (33.05 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6723 mL18.3614 mL36.7229 mL183.6143 mL
5 mM0.7345 mL3.6723 mL7.3446 mL36.7229 mL
10 mM0.3672 mL1.8361 mL3.6723 mL18.3614 mL
20 mM0.1836 mL0.9181 mL1.8361 mL9.1807 mL

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